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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 125 - 130 (6page)
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초록· 키워드
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Background/Aims: Chronic hepatitis C (CHC) is a major comorbidity in patients with hemophilia. However, there are no published data on the efficacy of antiviral therapy in Korea. We assessed the safety and efficacy of combination therapy with peginterferon α-2a plus ribavirin for CHC in hemophilia.
Methods: Patients (n=115) were enrolled between March 2007 and December 2008. Seventy-seven patients were genotype 1 or 6, and 38 patients were genotype 2 or 3. We evaluated rapid virologic responses (RVRs), early virologic response (EVRs), end-of-treatment response (ETRs), sustained virologic response (SVRs), and relapses. Safety evaluations included adverse events and laboratory tests.
Results: Eleven patients were excluded from the study because they had been treated previously. Among the remaining 104 treatment-naïve patients, RVR was achieved in 64 (60.6%), ETR was achieved in 95 (91.3%), and SVR was achieved in 89 (85.6%). Relapse occurred in eight patients (8.9%). Common adverse events were hair loss (56.7%) and headache (51.0%). Common hematologic adverse events were neutropenia (22.1%), anemia (27.9%), and thrombocytopenia (3.8%). However, there were no serious adverse events such as bleeding. RVR was the only predictor of SVR in multivariate analysis.
Conclusions: Peginterferon α-2a plus ribavirin combination treatment produced a favorable response rate in CHC patients with hemophilia without serious adverse events. (Clin Mol Hepatol 2015;21:125-130)
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참고문헌 (19)
참고문헌 신청
Alavian SM / 2010 / Peginterferon alpha-2a and ribavirin treatment of patients with haemophilia and hepatitis C virus infection : a single-centre study of 367 cases / Liver
EASL / 2011 / EASL Clinical Practice Guidelines : management of hepatitis C virus infection / J Hepatol 55 : 245 ~ 264
Franchini M / 2008 / Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin : a meta-analysis / J Antimicrob Chemother 61 : 1191 ~ 1200
Fried MW / 2002 / Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection / N Engl J Med 347 : 975 ~ 982
Ge D / 2009 / Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance / Nature 461 : 399 ~ 401
EASL / 2011 / EASL Clinical Practice Guidelines : management of hepatitis C virus infection / J Hepatol 55 : 245 ~ 264
Franchini M / 2008 / Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin : a meta-analysis / J Antimicrob Chemother 61 : 1191 ~ 1200
Fried MW / 2002 / Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection / N Engl J Med 347 : 975 ~ 982
Ge D / 2009 / Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance / Nature 461 : 399 ~ 401
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