지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아내분비학회 Annals of Pediatirc Endocrinology & Metabolism Annals of Pediatirc Endocrinology & Metabolism 제21권 제1호
- 발행연도
- 2016.1
- 수록면
- 21 - 25 (5page)
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초록· 키워드
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Purpose: Most surviving pediatric osteosarcoma patients experience osteoporosis, bone pain, and pathologic fracture during and after therapy. The aim of this study was to evaluate the efficacy and side effects of pamidronate therapy in these patients.
Methods: Nine osteosarcoma patients (12.8±1.6 years of age; 5 boys and 4 girls) who had a history of nontraumatic fracture or severe pain after completing chemotherapy were included. Intravenous pamidronate (1.5 mg/kg) was given every 6 weeks for 4 to 6 cycles. Bone mineral density (BMD) of the lumbar spine was measured by dual-energy x-ray absorptiometry. Clinical outcomes including acute side effects were also evaluated.
Results: After pamidronate treatments, all patients experienced decreased pain.
Seven of 9 patients could walk without a crutch. The BMD of lumbar spine was increased by 0.108±0.062 mg/cm2 after 8.4±1.0 months (n=8, P=0.017) and the mean z-score improved from –2.14±0.94 to –1.76±0.95 (P=0.161). Six patients (67%) had an acute-phase reaction, and 2 patients had symptomatic hypocalcemia.
Conclusion: Pamidronate appears to be safe and effective for the treatment of osteosarcoma in children with low BMD and bone pain.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Ottaviani G / 2009 / The epidemiology of osteosarcoma / Cancer Treat Res 152:3~13
Holzer G / 2003 / Bone mineral density in long-term survivors of highly malignant osteosarcoma / J Bone Joint Surg Br 85:231~237
Lim JS / 2013 / Young age at diagnosis, male sex, and decreased lean mass are risk factors of osteoporosis in long-term survivors of osteosarcoma / J Pediatr Hematol Oncol 35:54~60
Ju Hyun Ahn / 2015 / Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma / Annals of Pediatirc Endocrinology & Metabolism 20(3):150~154
Pirker-Fruhauf UM / 2012 / Osteoporosis in children and young adults: a late effect after chemotherapy for bone sarcoma / Clin Orthop Relat Res 470:2874~2885
Holzer G / 2003 / Bone mineral density in long-term survivors of highly malignant osteosarcoma / J Bone Joint Surg Br 85:231~237
Lim JS / 2013 / Young age at diagnosis, male sex, and decreased lean mass are risk factors of osteoporosis in long-term survivors of osteosarcoma / J Pediatr Hematol Oncol 35:54~60
Ju Hyun Ahn / 2015 / Bone mineral density change during adjuvant chemotherapy in pediatric osteosarcoma / Annals of Pediatirc Endocrinology & Metabolism 20(3):150~154
Pirker-Fruhauf UM / 2012 / Osteoporosis in children and young adults: a late effect after chemotherapy for bone sarcoma / Clin Orthop Relat Res 470:2874~2885
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