지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Aspirin resistance defined by light transmittance aggregometry (LTA) or urinary 11-dehydro-thromboxane B2 has been associated with an increased risk of adverse clinical events. However, aspirin resistance based on the point-of-care VerifyNow-Aspirin assay (aspirin reaction unit ≥550) shows poor sensitivity compared with LTA. In aspirin-treated patients, activation by cyclooxygenase–independent pathways may be associated with residual platelet reactivity, which may cause adverse clinical outcomes in some portion. A large-scale, prospective study using several platelet function assays should be performed to establish the long-term clinical significance of antiplatelet resistance in Korean patients treated with coronary stenting. Accordingly, we can apply tailored antiplatelet therapy in resistant patients.
목차
등록된 정보가 없습니다.
참고문헌 (10)
참고문헌 신청
Cattaneo M / 2007 / Resistance to antiplatelet drugs: molecular mechanisms and laboratory detection / J Thromb Haemost 5 (1) : 230 ~ 237
Eikelboom JW / 2008 / Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators. Incomplete inhibition of throm
FitzGerald GA / 1983 / Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man / J Clin Invest 71 : 676
Frelinger AL / 2008 / Aspirin ‘resistance’: role of pre-existent platelet reactivity and correlation between tests / J Thromb Haemost 6 : 2035 ~ 2044
Frelinger AL 3rd / 2006 / Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent
Eikelboom JW / 2008 / Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA) Investigators. Incomplete inhibition of throm
FitzGerald GA / 1983 / Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man / J Clin Invest 71 : 676
Frelinger AL / 2008 / Aspirin ‘resistance’: role of pre-existent platelet reactivity and correlation between tests / J Thromb Haemost 6 : 2035 ~ 2044
Frelinger AL 3rd / 2006 / Residual arachidonic acid-induced platelet activation via an adenosine diphosphate-dependent but cyclooxygenase-1- and cyclooxygenase-2-independent
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