지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 251 - 257 (7page)
이용수
초록· 키워드
오류제보하기
Background : Aspirin is the most common drug used for the prevention of arterial thrombosis. However, platelet responsiveness to aspirin is variable among individuals and it is important to detect aspirin resistance to improve clinical outcome. We analyzed the changes of platelet reactivity before
and after aspirin treatment. We also investigated the incidence and influencing factors of aspirin resistance in Korean.
Methods : We tested platelet function in 198 patients who had been treated with aspirin in a Korean university hospital, and 59 of these patients were tested for platelet function before and after aspirin treatment. We also analyzed platelet reactivity in 136 patients who had not been treated with aspirin. Platelet function was tested using the VerifyNow Aspirin Assay (Accumetrics, USA). Platelet reactivity was expressed as aspirin reaction unit (ARU) and ≥550 ARU was defined as aspirin resistance.
Results : Platelet reactivity of 136 patients who had not been treated with aspirin was 632.2±46.3 ARU (mean±SD) (range, 462-675). Platelet reactivity of 198 patients who had been treated with aspirin was 472.5±60.0 (338-666) ARU, and 10.1% of patients were aspirin-resistant. The difference
of platelet reactivity before and after aspirin treatment was 128.3±68.7 (-40-248) ARU. Hb level was lower and platelet count was higher in aspirin-resistant group than in aspirin-sensitive group (P<0.05).
Conclusions : We demonstrated the distribution of platelet reactivity before and after aspirin treatment using the VerifyNow Aspirin Assay. The incidence of aspirin resistance was 10.1%, and low Hb level and high platelet count were related with aspirin resistance. (Korean J Lab Med 2008;28:251-7)
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Alberts MJ / 2004 / Antiplatelet effect of aspirin in patients with cerebrovascular disease / Stroke 35 : 175 ~ 178
Andersen K / 2002 / Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease / Thromb Res : 37 ~ 42
Bruno A / 2004 / Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction / Stroke 35 : 727 ~ 730
Cambria-Kiely JA / 2002 / Possible mechanisms of aspirin resistance / J Thromb Thrombolysis 13 : 49 ~ 56
Cattaneo M. / 2007 / Laboratory detection of ‘aspirin resistance’: what test should we use (if any)? / Eur Heart J 28 : 1673 ~ 1675
Andersen K / 2002 / Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease / Thromb Res : 37 ~ 42
Bruno A / 2004 / Serial urinary 11-dehydrothromboxane B2, aspirin dose, and vascular events in blacks after recent cerebral infarction / Stroke 35 : 727 ~ 730
Cambria-Kiely JA / 2002 / Possible mechanisms of aspirin resistance / J Thromb Thrombolysis 13 : 49 ~ 56
Cattaneo M. / 2007 / Laboratory detection of ‘aspirin resistance’: what test should we use (if any)? / Eur Heart J 28 : 1673 ~ 1675
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