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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제35권 제3호
- 발행연도
- 2005.1
- 수록면
- 675 - 686 (12page)
이용수
초록· 키워드
오류제보하기
Bone resorption involves sequential stages of osteoclast precursor migration and differen- tiation of osteoclast precursors into multinucleated osteoclasts. Stromal cell derived factor (SDF)-1 is a chemotactic factor for osteoclast precursor migration. Matrix metalloproteinase (MMP)-9 is involved in migration of osteoclast precursors and activation of interleukin(IL)-1β. Alveolar bone destruction is a characteristic feature of periodontal disease. Treponema lecithinolyticum is a oral spirochete isolated from the periodontal lesions. The effect of lipopolysaccharide(LPS) from T. lecithinolyticum on expression of SDF-1 and MMP-9 was examined in cocultures of bone marrow cells and osteblasts derived from mouse calvariae.
T. lecithinolyticum LPS increased expression of MMP-9 in the coculture. Polymyxin B, an inhibitor of LPS, abolished the increase of MMP-9 mRNA expression by LPS. LPS did not increase the expression of SDF-1, IL-1β and tumor necrosis factor(TNF)-α mRNA in cocultures. Prostaglandin E2(PGE2) up-regulated the expression of MMP-9 and NS398, an inhibitor of PGE2 synthesis, down-regulated the induction of MMP-9 expression by T. lecithinolyticm LPS.
These results suggest that T. lecithinolytium LPS increases MMP-9 expression in bone cells via PGE2 and that the induction of MMP-9 expression by T. lecithinolyticum LPS is involved in alveolar bone destruction of periodontitis patients by the increase of osteoclast precursor migration and the activation of bone resorption-inducing cytokine.
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참고문헌 (27)
참고문헌 신청
/ / A new member of tumor necrosis factor ligand family : 449 ~ 455
/ 1985 / Mammalian collagenase predisposes bone surfaces to osteoclastic resorption 241 : 671 ~ 675
/ 1988 / The role of spirochetes in periodontal disease.Adv Dent Res 2 : 275 ~ 283
/ 1994 / Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive perio- dontitis 62 : 1889 ~ 1895
/ 1996 / a small oral spi- rochete isolated from human periodon- tal lesions (v) : 745 ~ 752
/ 1985 / Mammalian collagenase predisposes bone surfaces to osteoclastic resorption 241 : 671 ~ 675
/ 1988 / The role of spirochetes in periodontal disease.Adv Dent Res 2 : 275 ~ 283
/ 1994 / Diversity of cultivable and uncultivable oral spirochetes from a patient with severe destructive perio- dontitis 62 : 1889 ~ 1895
/ 1996 / a small oral spi- rochete isolated from human periodon- tal lesions (v) : 745 ~ 752
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