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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 746 - 753 (8page)
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Purpose: The present study investigated the dynamics and prognostic role of messenger RNA (mRNA) expression responsible for18F-fluorodeoxyglucose (FDG) uptake in FDG positron emission tomography (PET) and radioactive iodine (131I) uptake in wholebodyradioactive iodine scans (WBS) in papillary thyroid cancer (PTC) patients. Materials and Methods: The primary and processed data were downloaded from the Genomic Data Commons Data Portal. Expressiondata for sodium/iodide symporter (solute carrier family 5 member 5, SLC5A5), hexokinase (HK1–3), glucose-6-phosphatedehydrogenase (G6PD), and glucose transporter (solute carrier family 2, SLC2A1–4) mRNA were collected. Results: Expression of SLC5A5 mRNA were negatively correlated with SLC2A1 mRNA and positively correlated with SLC2A4mRNA. In PTC with BRAF mutations, expressions of SLC2A1, SLC2A3, HK2, and HK3 mRNA were higher than those in PTC withoutBRAF mutations. Expression of SLC5A5, SLC2A4, HK1, and G6PD mRNA was lower in PTC without BRAF mutation. PTCswith higher expression of SLC5A5 mRNA had more favorable disease-free survival, but no association with overall survival. Conclusion: Expression of SLC5A5 mRNA was negatively correlated with SLC2A1 mRNA. This finding provides a molecular basisfor the management of PTC with negative WBS using 18F-FDG PET scans. In addition, higher expression of SLC5A5 mRNA wasassociated with less PTC recurrence, but not with deaths.
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참고문헌 (26)
참고문헌 신청
Cabanillas ME / 2016 / Thyroid cancer / Lancet 388:2783~2795
Ahn HS / 2015 / South Korea's thyroid-cancer "Epidemic"--turning the tide / N Engl J Med 373:2389~2390
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133
Pak K / 2014 / Prognostic value of metabolic tumor volume and total lesion glycolysis in head and neck cancer: a systematic review and metaanalysis / J Nucl Med 55:884~890
Tavares C / 2016 / ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome / Eur J Endocrinol 174:R117~R126
Ahn HS / 2015 / South Korea's thyroid-cancer "Epidemic"--turning the tide / N Engl J Med 373:2389~2390
Haugen BR / 2016 / 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: The American Thyroid Association Guidelines Task Force on thyroid nodules and differentiated thyroid cancer / Thyroid 26:1~133
Pak K / 2014 / Prognostic value of metabolic tumor volume and total lesion glycolysis in head and neck cancer: a systematic review and metaanalysis / J Nucl Med 55:884~890
Tavares C / 2016 / ENDOCRINE TUMOURS: Genetic predictors of thyroid cancer outcome / Eur J Endocrinol 174:R117~R126
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