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학술저널
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연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제59권 제7호
발행연도
2018.1
수록면
897 - 903 (7page)

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Purpose: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social communication impairmentsand repetitive behaviors or restricted interests. Impaired pragmatic language comprehension is a universal feature in individualswith ASD. However, the underlying neural basis of pragmatic language is poorly understood. In the present study, we examinedneural activation patterns associated with impaired pragmatic language comprehension in ASD, compared to typicallydeveloping children (TDC). Materials and Methods: Functional magnetic resonance imaging (fMRI) was applied to 15 children with ASD and 18 TDC usingthe Korean pragmatic language task. Results: Children with ASD were less accurate than TDC at comprehending idioms, particularly when they were required to interpretidioms with mismatched images (mismatched condition). Children with ASD also showed different patterns of neural activitythan TDC in all three conditions (neutral, matched, and mismatched). Specifically, children with ASD showed decreased activationin the right inferior frontal gyrus (IFG) (Brodmann area 47) in the mismatched condition, compared with TDC (IFG; t(31)=3.17,p<0.001). Conclusion: These results suggest that children with ASD face difficulties in comprehending pragmatic expressions and applydifferent pragmatic language processes at the neural level.

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