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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 58 - 65 (8page)
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Purpose: The purpose of this study is to describe the rate of cytomegalovirus (CMV) virolactia, and the prevalence of breast milk (BM)-transmitted postnatal CMV infection among premature infants after freeze-thawing (FT) and Holder pasteurization (HP) of breast milk. Methods: This is a single-center, retrospective study of 312 infants born at less than 32 weeks of gestation, or with a birth weight less than 1,500 g from January 2013 to June 2017. All infants were screened for CMV-specific immunoglobulin (Ig) G and IgM at birth. Initial CMV specific polymerase chain reaction (PCR) and CMV culture were performed on mothers’ BM and babies’ urine within the first 21 days of life. FT and HP of BM was used to prevent the transmission of CMV. For the surveillance of postnatal CMV infection, CMV culture and CMV specific PCR of urine from babies were repeated one to two months after the initial screening. Screening for viremia and viruria was performed if postnatal CMV infection was suspected. Results: Among 178 BM samples obtained from mothers of CMV-IgG-seropositive infants, 80 (44.9%) were CMV PCR positive. CMV deoxyribonucleic acid (DNA) was detected in five of the 22 BM samples (22.7%) obtained from the mothers of CMV-IgG seronegative infants. When CMV DNA load in BM was measured before and after HP, various results were shown. Sixty-three infants out of 232 (27.2%) were evaluated for postnatal CMV infection and four infants out of 63 (6.3%) were infected. Conclusion: Interventions to prevent BM-transmitted CMV infection can reduce the chance of postnatal CMV infection, but not completely eliminate it.
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등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Lanzieri TM / 2013 / Breast milk-acquired cytomegalovirus infection and disease in VLBW and premature infants / Pediatrics 131:e1937~e1945
Ai Rhan Ellen Kim / 2006 / Transfusion-related Cytomegalovirus Infection Among Very Low Birth Weight Infants in an Endemic Area / Journal of Korean Medical Science 21(1):5~10
Swanson EC / 2013 / Congenital cytomegalovirus infection: new prospects for prevention and therapy / Pediatr Clin North Am 60:335~349
Ehlinger EP / 2011 / Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants / J Infect Dis 204:1672~1682
Sohn YM / 1992 / Congenital cytomegalovirus infection in Korean population with very high prevalence of maternal immunity / J Korean Med Sci 7:47~51
Ai Rhan Ellen Kim / 2006 / Transfusion-related Cytomegalovirus Infection Among Very Low Birth Weight Infants in an Endemic Area / Journal of Korean Medical Science 21(1):5~10
Swanson EC / 2013 / Congenital cytomegalovirus infection: new prospects for prevention and therapy / Pediatr Clin North Am 60:335~349
Ehlinger EP / 2011 / Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants / J Infect Dis 204:1672~1682
Sohn YM / 1992 / Congenital cytomegalovirus infection in Korean population with very high prevalence of maternal immunity / J Korean Med Sci 7:47~51
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