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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.3
- 수록면
- 11 - 18 (8page)
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초록· 키워드
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Human cytomegalovirus (CMV) continues to be a major threat against solid-organ transplant recipients despite significant advancements in its prophylaxis and therapy. Primary CMV infection or reactivation of latent CMV in the transplant recipients may cause CMV diseases such as flu-like viral syndrome and tissue-invasive CMV disease. In addition, CMV infection in the recipients is associated with graft rejection and higher risk of other opportunistic infections, which are collectively known as the "indirect effects" of CMV infection. Prevention strategies with antiviral drugs including ganciclovir remarkably decreased CMV disease and the "indirect effects". Two commonly employed strategies are universal prophylaxis and preemptive therapy. However, gangciclovir-resistant CMV has emerged due to mutations in CMV UL97 and UL54 genes, now requiring alternative therapeutic options to be developed. This review provides an overview of CMV infection and disease, "indirect effects" on hosts, prevention strategies, and drug resistance in solid-organ transplant recipients.
목차
Ⅰ. INTRODUCTION
Ⅱ. CMV infection and disease
Ⅲ. Indirect effects on grafts and recipients
Ⅳ. Prevention strategies
Ⅴ. Drug resistance
Ⅵ. Closing remarks
REFERENCES
참고문헌 (50)
참고문헌 신청
1. [학술지(정기간행물)] - Davison AJ / 2003 / The human cytomegalovirus genome revisited: comparison with the chimpanzee cytomegalovirus genome / J Gen Virol 84 : 17 ~ 28
2. [학술지(정기간행물)] - Söderberg-Nauclér C / 2006 / Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer / J Intern Med 259 : 219 ~ 246
3. [학술지(정기간행물)] - Kotton CN / 2013 / Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation / Transplantation 96 : 333 ~ 360
4. [학술지(정기간행물)] - Ljungman P / 2002 / Definitions of cytomegalovirus infection and disease in transplant recipients / Clin Infect Dis 34 : 1094 ~ 1097
5. [학술지(정기간행물)] - Razonable RR / 2008 / Cytomegalovirus infection after liver transplantation: current concepts and challenges / World J Gastroenterol 14 : 4849 ~ 4860
2. [학술지(정기간행물)] - Söderberg-Nauclér C / 2006 / Does cytomegalovirus play a causative role in the development of various inflammatory diseases and cancer / J Intern Med 259 : 219 ~ 246
3. [학술지(정기간행물)] - Kotton CN / 2013 / Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation / Transplantation 96 : 333 ~ 360
4. [학술지(정기간행물)] - Ljungman P / 2002 / Definitions of cytomegalovirus infection and disease in transplant recipients / Clin Infect Dis 34 : 1094 ~ 1097
5. [학술지(정기간행물)] - Razonable RR / 2008 / Cytomegalovirus infection after liver transplantation: current concepts and challenges / World J Gastroenterol 14 : 4849 ~ 4860
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