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논문 기본 정보

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학술저널
저자정보
Huh Kyungmin (Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Lee Sang-Oh (Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Jungok (Division of Infectious Diseases, Department of Medicine, Chungnam National University School of Medicine, Daejeon, Korea.) Lee Su Jin (Division of Infectious Diseases, Department of Internal Medicine, Pusan National University School of Medicine, Yangsan, Korea.) Choe Pyoeng Gyun (Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.) Kang Ji-Man (Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, Korea.Institute for Immunology and Immunological Diseases, Yonsei University College of) Yang Jaeseok (Department of Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea.) Sung Heungsup (Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.) Kim Si-Ho (Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.) Moon Chisook (Division of Infectious Diseases, Department of Internal Medicine, Inje University Busan Paik Hospital, College of Medicine, Busan, Korea.) Seok Hyeri (Division of Infectious Diseases, Department of Internal Medicine, Korea University Ansan Hospital, Korea University Medicine, Ansan, Korea.) Shi Hye Jin (Division of Infectious Diseases, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.) Wi Yu Mi (Division of Infectious Diseases, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Korea.) Jeong Su Jin (Division of Infectious Diseases, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.) Park Wan Beom (Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.) Kim Youn Jeong (Division of Infectious Diseases, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.) Kim Jong Man (Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Ahn Hyung Joon (Department of Surgery, College of Medicine, Kyung Hee University, Seoul, Korea.) Kim Nam Joong (Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.) Peck Kyong Ran (Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.) Kim Myoung Soo (Department of Surgery, The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.) Kim Sang Il (Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.)
저널정보
대한감염학회 Infection and Chemotherapy Infection and Chemotherapy Vol.56 No.1
발행연도
2024.3
수록면
101 - 121 (21page)
DOI
10.3947/ic.2024.0016

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초록· 키워드

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Cytomegalovirus (CMV) is the most important opportunistic viral pathogen in solid organ transplant (SOT) recipients. The Korean guideline for the prevention of CMV infection in SOT recipients was developed jointly by the Korean Society for Infectious Diseases and the Korean Society of Transplantation. CMV serostatus of both donors and recipients should be screened before transplantation to best assess the risk of CMV infection after SOT. Seronegative recipients receiving organs from seropositive donors face the highest risk, followed by seropositive recipients. Either antiviral prophylaxis or preemptive therapy can be used to prevent CMV infection. While both strategies have been demonstrated to prevent CMV infection post-transplant, each has its own advantages and disadvantages. CMV serostatus, transplant organ, other risk factors, and practical issues should be considered for the selection of preventive measures. There is no universal viral load threshold to guide treatment in preemptive therapy. Each institution should define and validate its own threshold. Valganciclovir is the favored agent for both prophylaxis and preemptive therapy. The evaluation of CMV-specific cell-mediated immunity and the monitoring of viral load kinetics are gaining interest, but there was insufficient evidence to issue recommendations. Specific considerations on pediatric transplant recipients are included.
#Organ transplantation #Cytomegalovirus #Prevention

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