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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 255 - 261 (7page)
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Background: Cytomegalovirus (CMV) is the main infectious agent causative of morbidity and mortality in transplant recipients. This study aimed to describe the occurrence and clinical features of CMV infection, and the optimum antigenemia assay cutoff associated with symptomatic infection.
Materials and Methods: This was a cohort study that investigated 87 patients undergoing renal transplantation. The patients were monitored with the CMV antigenemia assay performed weekly for the first 3 months post-transplantation and subsequently, when CMV infection was suspected clinically.
Results: CMV infection was observed in 63.2% (55/87) of the recipients during the follow-up. Of the 65 episodes observed, 75% (49/65) occurred until 100 days after transplantation (D+100) and 25% (16/65) after D+100 with a median of 60 days. CMV infection was associated with age of the transplant recipients (P = 0.001) and use of deceased donor organ (P = 0.009). There were asymptomatic (34%) and symptomatic (66%) episodes of CMV infection, in which diarrhea was the most common symptom (22.6%), followed by elevated creatinine levels (14.5%), fever (12.9%) and leukopenia (10.5%). The optimum cutoff point associated with symptomatic infection was 5 positive cells/200,000 leukocytes (area under the curve = 0.87, positive predictive value = 88% and negative predictive value= 71%).
Conclusion: The high occurrence and the risk factors for CMV infection such as the age of recipients, the number of positive cells in the antigenemia assay, and use of a deceased donor organ should be considered for appropriate monitoring and management of kidney recipients during the post-transplant period.
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참고문헌 (20)
참고문헌 신청
Andrews PA / 2011 / Summary of the British transplantation society guidelines for the prevention and management of CMV disease after solid organ transplantation / Transplant
Atkinson C / 2011 / Cytomegalovirus quantification: where to next in optimising patient management? / J Clin Virol 51 : 223 ~ 228
Browne BJ / 2010 / The impact of cytomegalovirus infection ≥1 year after primary renal transplantation / Clin Transplant 24 : 572 ~ 577
Cordero E / 2012 / Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors / Transplant Proc 44 : 694 ~ 700
De Keyzer K / 2011 / Human cytomegalovirus and kidney transplantation: a clinician's update / Am J Kidney Dis 58 : 118 ~ 126
Atkinson C / 2011 / Cytomegalovirus quantification: where to next in optimising patient management? / J Clin Virol 51 : 223 ~ 228
Browne BJ / 2010 / The impact of cytomegalovirus infection ≥1 year after primary renal transplantation / Clin Transplant 24 : 572 ~ 577
Cordero E / 2012 / Cytomegalovirus disease in kidney transplant recipients: incidence, clinical profile, and risk factors / Transplant Proc 44 : 694 ~ 700
De Keyzer K / 2011 / Human cytomegalovirus and kidney transplantation: a clinician's update / Am J Kidney Dis 58 : 118 ~ 126
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