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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2006.1
- 수록면
- 217 - 229 (13page)
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Oxidative stress plays critical roles in airway inflammation that is usually accompanied by increased vascular permeability and plasma exudation. VEGF increases vascular permeability and leads to airway inflammation. In addition, VEGF has been shown to enhance receptor activator of NF-κB (RANK) expression in endothelial cells. An aim of the study was to determine the potential role of antioxidant in the regulation of RANK expression in murine model of asthma. We have used a C57BL/6 mouse model of allergic asthma to evaluate the effect of L-2-oxothiazolidine-4-carboxylic acid (OTC), a prodrug of cysteine, which acts as an antioxidant, and VEGF receptor inhibitor on RANK mRNA expression. The mice develop the following pathophysiological features of asthma in the lungs: increased expression of RANK mRNA, increased number of inflammatory cells of the airways, increased vascular permeability, and increased levels of VEGF. Administration of OTC and VEGF receptor inhibitor markedly reduced plasma extravasation and VEGF levels in allergen-induced asthmatic lungs. We also showed that the increased RANK mRNA expression at 72 h after ovalbumin inhalation were reduced by the administration of OTC or VEGF receptor inhibitor. The results indicate that OTC and VEGF receptor inhibitor which inhibit up-regulation of VEGF expression modulate RANK expression that may be in association with the regulation of vascular permeability, and suggest that VEGF may regulate the RANK expression. These findings provide a crucial molecular mechanism for the potential use of antioxidants to prevent and/or treat asthma and other airway inflammatory disorders.
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참고문헌 (26)
참고문헌 신청
[학술지(정기
Anderson DM / 1997 / A homologue of the TNF receptor and its ligand en-hance T-cell growth and dendritic-cell function 390 : 175 ~ 9
Asti C / 1995 / Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness 31 : 387 ~ 92
Bachmann MF / 1999 / TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. 189 : 1025 ~ 31
Blesa S / 2002 / Effectiveness of oral N-acetylcys-teine in a rat experimental model of asthma 45 : 135 ~ 40
Anderson DM / 1997 / A homologue of the TNF receptor and its ligand en-hance T-cell growth and dendritic-cell function 390 : 175 ~ 9
Asti C / 1995 / Effectiveness of carbocysteine lysine salt monohydrate on models of airway inflammation and hyperresponsiveness 31 : 387 ~ 92
Bachmann MF / 1999 / TRANCE, a tumor necrosis factor family member critical for CD40 ligand-independent T helper cell activation. 189 : 1025 ~ 31
Blesa S / 2002 / Effectiveness of oral N-acetylcys-teine in a rat experimental model of asthma 45 : 135 ~ 40
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