지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 514 - 523 (10page)
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Angiogenesis is critical and indispensable for tumor progression. Since VEGF is known to play a central role in angiogenesis, the disruption of VEGF-VEGF receptor system is a promising target for anti-cancer therapy. Previously, we reported that a hexapeptide (RRKRRR, RK6) blocked the growth and metastasis of tumor by inhibiting VEGF binding to its receptors. In addition, dRK6, the D-form derivative of RK6, retained its biological activity with improved serum stability. In the present study, we developed a serum-stable branched dimeric peptide (MAP2-dRK6) with enhanced anti-VEGF and anti-tumor activity. MAP2-dRK6is more effective than dRK6 in many respects: inhibition of VEGF binding to its receptors, VEGF- and tumor conditioned medium-induced proliferation and ERK signaling of endothelial cells, and VEGF-induced migration and tube formation of endothelial cells.
Moreover, MAP2-dRK6 blocks in vivo growth of VEGF-secreting colorectal cancer cells by the suppression of angiogenesis and the subsequent induction of tumor cell apoptosis. Our observations suggest that MAP2-dRK6 can be a prospective therapeutic molecule or lead compound for the development of drugs for various VEGF-related angiogenic diseases.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)]
Aiello LP / 1995 / Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins / Proc
Bae DG / 2000 / Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis / J Biol Chem 275 : 13588 ~ 13596
Bae YS / 2003 / Novel chemoattractant peptides for human leukocytes / Biochem Pharmacol 66 : 1841 ~ 1851
Blondelle SE / 1996 / Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents / Antimicrob Agents Chemother 40 : 1067 ~ 1071
Aiello LP / 1995 / Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins / Proc
Bae DG / 2000 / Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis / J Biol Chem 275 : 13588 ~ 13596
Bae YS / 2003 / Novel chemoattractant peptides for human leukocytes / Biochem Pharmacol 66 : 1841 ~ 1851
Blondelle SE / 1996 / Synthetic combinatorial libraries: novel discovery strategy for identification of antimicrobial agents / Antimicrob Agents Chemother 40 : 1067 ~ 1071
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