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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2005.1
- 수록면
- 619 - 623 (5page)
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A C6 β-chemokine, CKβ8-1, suppressed the colony formation of CD34+cells of human cord blood (CB). Molecular mechanisms involved in CKβ8-1-medi-cated suppression of colony formation of CD34+ cells are not known. To address this issue, the level of various G1/S cell cycle regulating proteins in CKβ8-1-treated CD34+cells were compared with those in untreated CD34+ cells. CKβ8-1 did not sig-nificantly alter the expression of the G1/S cycle regulation proteins (cyclin D1, D3, and E), CDK in-hibitor (p27and Rb), and other cell proliferation regulation protein (p53) in CB CD34+ cells. Here we describe an in vitro system in which CB CD34+ cells were committed to a multipotent progenitor lineage of colony forming units-granulocyte/macrophage (CFU-GM) by a simple combination of recombinant human (rh) GM-CSF and rhIL-3. In this culture system, we found that cyclin E protein appeared later and disappeared faster in the CKβ8-1-treated cells than CFU-GM lineage develop-ment. These findings suggested that cyclin E may play a role in suppressing the colony formation of CFU-GM by CKβ8-1.
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참고문헌 (19)
참고문헌 신청
/ .1999 / Smith FO. Cord blood stem cell trans-plantation. In Stem Cell Transplantation : 431 ~ 443
/ / Almasan A. A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. Curr Cancer Drug Targets 2004 : 65 ~ 75
/ / Aronica SM. Biology and me-chanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines. Stem Cells 1997 15 : 15 6
/ / Boonstra J. Progression through the G1-phase of the on- going cell cycle. J Cell Biochem 2003 : 244 ~ 52
/ / Briere J. Platelet factor 4 inhibits human megakaryocytopoiesis in vitro. Blood 1990 : 1234 ~ 9
/ / Almasan A. A dual role of cyclin E in cell proliferation and apoptosis may provide a target for cancer therapy. Curr Cancer Drug Targets 2004 : 65 ~ 75
/ / Aronica SM. Biology and me-chanisms of action of synergistically stimulated myeloid progenitor cell proliferation and suppression by chemokines. Stem Cells 1997 15 : 15 6
/ / Boonstra J. Progression through the G1-phase of the on- going cell cycle. J Cell Biochem 2003 : 244 ~ 52
/ / Briere J. Platelet factor 4 inhibits human megakaryocytopoiesis in vitro. Blood 1990 : 1234 ~ 9
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