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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2010.1
- 수록면
- 703 - 711 (9page)
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Heat shock protein 90 (HSP90), one of the most abundant proteins in the cardiac cells is essential for cell survival. Previous studies have shown that angiotensin II induces cardiac cell hypertrophy. However,the role of HSP90 in the angiotensin II-induced cardiac hypertrophy is unclear. In this study, we showed that HSP90 regulated angiotensin II-induced hypertrophy via maintenance of the IκB kinase (IKK) complex stability in cardiac cells. An HSP90 inhibitor, geldanamycin (GA), significantly suppressed angiotensin II-induced [3H]leucine incorporation and atrial natriuretic factor expression in cardiac cells. GA also inhibited the NF-κB activation induced by angiotensin II. Importantly,treatment with GA caused a degradation of IKKα/β; on the other hand, a proteasome-specific inhibitor restored the level of IKKα/β. We also found that GA prevented HSP90-IKKs complex induced by angiotensin II in cardiac cells. The small interfering RNA (siRNA)-mediated knockdown of HSP90 expression significantly inhibited angiotensin II-induced cell hypertrophy and NF-κB activation. These results suggest that angiotensin II-induced cardiac hypertrophy requires HSP90 that regulates the stability and complex of IKK.
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참고문헌 (23)
참고문헌 신청
[학술지(정기간행물)] -
Ammirante M / 2008 / The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors / Oncogene 27 : 1175 ~ 1178
Arthur JC / 2007 / Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase / J Immunol 179 : 6291 ~ 6296
Brasier AR / 2000 / Angiotensin II induces gene transcription through celltype- dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor / Mol Cell Bio
Broemer M / 2004 / Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation / Oncogene 23 : 5378 ~
Ammirante M / 2008 / The activity of hsp90 alpha promoter is regulated by NF-kappa B transcription factors / Oncogene 27 : 1175 ~ 1178
Arthur JC / 2007 / Heat shock protein 90 associates with monarch-1 and regulates its ability to promote degradation of NF-kappaB-inducing kinase / J Immunol 179 : 6291 ~ 6296
Brasier AR / 2000 / Angiotensin II induces gene transcription through celltype- dependent effects on the nuclear factor-kappaB (NF-kappaB) transcription factor / Mol Cell Bio
Broemer M / 2004 / Requirement of Hsp90 activity for IkappaB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-kappaB activation / Oncogene 23 : 5378 ~
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