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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제14권 제4호
- 발행연도
- 2004.1
- 수록면
- 881 - 884 (4page)
이용수
초록· 키워드
오류제보하기
Apoptosis inducers for cancer therapy have beenstudied. Among hundreds of inducers, peptide anticancerdrugs have many advantages such as being not harmful tohumans, high selectivity, and dependence on their structures.Naltriben (NTB) is an octapeptide consisting of DPhe-Cys-Tyr-DTrp-Orn-Thr-Pen-Thr-NH2. Several NTB analogues areknown. In this experiment, apoptotic activities of NTB analogueswith 8 amino acids were tested using flow cytometry. Theconformational study of NTB was carried out using NMRspectroscopy and molecular modeling. Here, the relationshipsbetween conformations of NTB analogues and their apoptoticeffects are reported.
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참고문헌 (10)
참고문헌 신청
Alam / 2003 / Apoptosis:Target for novel drugs 21 : 479 ~ 483
Bonner / 2000 / Opiate aromatic pharmacophore structureactivityrelationships in CTAP analogues determined bytopographical bias, two-dimensional NMR, and biologicalactivity as
Jeong / 2002 / Growth inhibition andapoptosis induction of gastric cancer cells by copper (II)glycinate complex 12 : 394 ~ 399
Kim / 2001 / Pharmacological effects of naltriben as a ligand for opioid mand k receptors in rat cerebral cortex 68 : 1305 ~ 1315
Kim / 2003 / Inhibition of cell-cycleprogression in human promyelocytic leukemia HL-60 cellsby MCS-C2 13 : 607 ~ 612
Bonner / 2000 / Opiate aromatic pharmacophore structureactivityrelationships in CTAP analogues determined bytopographical bias, two-dimensional NMR, and biologicalactivity as
Jeong / 2002 / Growth inhibition andapoptosis induction of gastric cancer cells by copper (II)glycinate complex 12 : 394 ~ 399
Kim / 2001 / Pharmacological effects of naltriben as a ligand for opioid mand k receptors in rat cerebral cortex 68 : 1305 ~ 1315
Kim / 2003 / Inhibition of cell-cycleprogression in human promyelocytic leukemia HL-60 cellsby MCS-C2 13 : 607 ~ 612
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