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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제15권 제4호
- 발행연도
- 2005.1
- 수록면
- 887 - 890 (4page)
이용수
초록· 키워드
오류제보하기
To evaluate the hepatoprotective activity of lacticacid bacteria, their effects on tert-butylperoxide (t-BHP)-induced hepatotoxicity in mice were measured. When lacticacid bacteria at doses of 0.5 and 2 g (wet weight)/kg wereorally administered to mice with t-BHP-induced liver injury,these bacteria significantly inhibited the increase of plasmaalanine aminotransferase and aspartate aminotransferase activitiesby 17-57% and 57-66% of the t-BHP control group,respectively. However, these lactic acid bacteria did notprotect cytotoxicity induced by t-BHP against HepG2 cells.The inhibitory effects of these lactic acid bacteria at a dose of0.5 g/kg were comparable with that of diphenyl dimethylbicarboxylate at a dose of 0.2 g/kg, which has been used as acommercial hepatoprotective agent. Among these lactic acidbacteria, Bifidobacterium longum HY8001 exhibited the mostpotent hepatoprotective effect. These orally administered lacticacid bacteria inhibited liver lipid peroxidation on t-BHPinducedhepatotoxicity of mice. We suggest that lactic acidbacteria may be an effective agent against liver injury.
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등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ 1979 / Assay for lipidperoxides in animal tissues by thibarbituric acid reaction 95 : 35 ~ 41
/ 1990188-197 / Molecular mechanisms of oxygenradical carcinogenesis and mutagenesis The role of DNAbase damage carci (g)
/ 1999 / New insight to pathogenesis ora possible therapeutic alternative 116 : 1246 ~ 116 1260
A / 1990 / A model for studying antihepatotoxiccrude drugs : 171 ~ 174
Bradford,M / 1976 / A rapid and sensitive method for thequantitation of microgram quantities of protein utilizing theprinciple of protein dye binding 72 : 248 ~ 254
/ 1990188-197 / Molecular mechanisms of oxygenradical carcinogenesis and mutagenesis The role of DNAbase damage carci (g)
/ 1999 / New insight to pathogenesis ora possible therapeutic alternative 116 : 1246 ~ 116 1260
A / 1990 / A model for studying antihepatotoxiccrude drugs : 171 ~ 174
Bradford,M / 1976 / A rapid and sensitive method for thequantitation of microgram quantities of protein utilizing theprinciple of protein dye binding 72 : 248 ~ 254
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