지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 391 - 399 (9page)
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초록· 키워드
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Background: Allergic contact dermatitis (ACD), which is accelerated by interferon (IFN)-γ and suppressed by interleukin (IL)-10 as regulators, is generally self-limited after removal of the contact allergen. Adipose tissue-derived multipotent mesenchymal stem cells (ASCs) potentially exert immunomodulatory effects. Considering that subcutaneous adipose tissue is located close to the site of ACD and includes mesenchymal stem cells (MSCs), the MSCs in adipose tissue could contribute to the self-limiting course of ACD. Objective: The aims of the present study were to elucidate the effects of MSCs in adipose tissue on ACD and to examine any cytokine- mediated mechanisms involved. Methods: Ear thickness in a C57BL/6 mouse model of ACD using contact hypersensitivity (CHS) elicited by 2,4,6-trinitro-1-chlorobenzene was evaluated as a marker of inflammation level. Five and nine mice were injected with ASCs and phosphate-buffered saline (PBS), respectively. After ASC or PBS injection, real- time reverse transcription-polymerase chain reaction and enzyme-linked immunosorbent assay were performed.
Results: Histology showed that CHS was self-limited and ear thickness was suppressed by ASCs in a dose-dependent manner. IFN-γ expression in the elicited skin site and regional lymph nodes was significantly lower in ASC-treated mice than in control mice. IL-10 expression did not differ between treated and control mice. The suppressive effects of ASCs on CHS response did not differ between IL-10 knock-out C57BL/6 mice and wild-type mice. Conclusion: The present findings suggest that MSCs in adipose tissue may contribute to the self-limiting course of ACD through decreased expression of IFN-γ, but not through increased expression of IL-10.
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참고문헌 (17)
참고문헌 신청
Berg DJ / 1995 / Interleukin 10 but not interleukin 4 is a natural suppressant of cutaneous inflammatory responses / J Exp Med 182 : 99 ~ 108
Bobr A / 2012 / Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration / Proc Natl Acad Sci U S A 109 : 10492 ~ 10497
Cavani A / 2000 / Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses / J Invest Dermatol 114 : 295 ~ 30
Cavani A / 2001 / Effector and regulatory T cells in allergic contact dermatitis / Trends Immunol 22 : 118 ~ 120
Dominici M / 2006 / Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement / Cytotherapy 8 : 3
Bobr A / 2012 / Autocrine/paracrine TGF-β1 inhibits Langerhans cell migration / Proc Natl Acad Sci U S A 109 : 10492 ~ 10497
Cavani A / 2000 / Human CD4+ T lymphocytes with remarkable regulatory functions on dendritic cells and nickel-specific Th1 immune responses / J Invest Dermatol 114 : 295 ~ 30
Cavani A / 2001 / Effector and regulatory T cells in allergic contact dermatitis / Trends Immunol 22 : 118 ~ 120
Dominici M / 2006 / Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement / Cytotherapy 8 : 3
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