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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 100 - 107 (8page)
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Background/Aims: Inflammatory bowel disease (IBD) is an autoimmune disease characterized by chronic inflammation mainly in the large intestine. The interleukin-10 knockout (IL-10 KO) mouse is a well-known animal model of IBD that develops spontaneous intestinal inflammation resembling Crohn’s disease. Oxidative stress is considered to be the leading cause of cell and tissue damage. Reactive oxygen species (ROS) can cause direct cell injury and/or indirect cell injury by inducing the secretion of cytokines from damaged cells. This study evaluated the effects of mesenchymal stem cell (MSC) on the progression of IBD. Methods: In this study, human bone marrow-derived MSCs were injected into IL-10 KO mice (MSC). Oxidative stress and inflammation levels were evaluated in the large intestine and compared with those in control IL-10 KO mice (CON) and normal wild-type control mice (Wild). Results: The levels of ROS (superoxide and hydrogen peroxidase) and a secondary end-product of lipid peroxidation (malondialdehyde) were considerably higher in the CON, while superoxide dismutase and catalase levels were lower in the MSC. Inflammation-related marker (interferon-γ, tumor necrosis factor-α, IL-4, and CD8) expression and inflammatory histological changes were much less pronounced in MSC than in CON. Conclusions: MSCs affect the redox balance, leading to the suppression of IBD.
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참고문헌 (27)
참고문헌 신청
Sheehan D / 2017 / The gut microbiota in inflammatory bowel disease / Gastroenterol Clin North Am 46:143~154
de Lange KM / 2015 / Understanding inflammatory bowel disease via immunogenetics / J Autoimmun 64:91~100
Singh UP / 2008 / CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-)mice, which can be abrogated by anti-CXCL10 antibody inhibition / J Interferon Cytokine Res 28:31~43
Sheehan D / 2015 / The microbiota in inflammatory bowel disease / J Gastroenterol 50:495~507
Randall-Demllo S / 2013 / Intestinal epithelium and autophagy : partners in gut homeostasis / Front Immunol 4:301
de Lange KM / 2015 / Understanding inflammatory bowel disease via immunogenetics / J Autoimmun 64:91~100
Singh UP / 2008 / CXCL10-producing mucosal CD4+ T cells, NK cells, and NKT cells are associated with chronic colitis in IL-10(-/-)mice, which can be abrogated by anti-CXCL10 antibody inhibition / J Interferon Cytokine Res 28:31~43
Sheehan D / 2015 / The microbiota in inflammatory bowel disease / J Gastroenterol 50:495~507
Randall-Demllo S / 2013 / Intestinal epithelium and autophagy : partners in gut homeostasis / Front Immunol 4:301
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