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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 104 - 108 (5page)
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초록· 키워드
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The purpose of this study was to establish valerenic acid as a marker compound for the standardization of ethanol extract of Valerinan officinalis (valerian) root as a functional health food. We established valerenic acid as a marker compound using HPLC. HPLC was used to quantify the marker compound in the valerian extract after validation of methods with linearity, accuracy, and precision. The specificity for retention time was met by comparative analysis of the valerian extract and standard compound using HPLC. The method showed high linearity of the calibration curve with a coefficient of correlation (R2) of 0.9999. The limit of quantification (LOQ) was 10 μg/mL. The accuracy of measurement was 99.88~ 00.68% and the relative standard deviation (RSD) value was 0.59%. In addition, our analytical method yielded a 29% mean content of valerenic acid in the valerian ethanol extract. These results indicate that the established HPLC method facilitated the determination of marker compounds in the valerian extract for the standardization of health functional foods.
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등록된 정보가 없습니다.
참고문헌 (13)
참고문헌 신청
Becker A / 2014 / The anxiolytic effects of a valerian extract is based on valerenic acid / BMC Complement Altern Med 14:267
Debnath T / 2013 / Antioxidant activity of inonotus obliquus grown on germinated brown rice extracts / J Food Biochem 37:456~464
Donath F / 2000 / Critical evaluation of the effect valerian extract on sleep structure and sleep quality / Pharmacopsychiatry 33:47~53
Donovan JL / 2004 / Multiple night-time doses of valerian (Valeriana officinalis) had minimal effexts on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers / Drug Metab Dispos 32:1333~1336
Gray WS / 2005 / Use of solid phase extraction for improving HPLC assays of triterpene glycosides in gotu kola (Centella asiatica), parthenolide in feverfew (Tanacetum parthenium), and valerenic acids in valerian (Valeriana officinalis) / J Liq Chromatogr Relat Technol 28:581~592
Debnath T / 2013 / Antioxidant activity of inonotus obliquus grown on germinated brown rice extracts / J Food Biochem 37:456~464
Donath F / 2000 / Critical evaluation of the effect valerian extract on sleep structure and sleep quality / Pharmacopsychiatry 33:47~53
Donovan JL / 2004 / Multiple night-time doses of valerian (Valeriana officinalis) had minimal effexts on CYP3A4 activity and no effect on CYP2D6 activity in healthy volunteers / Drug Metab Dispos 32:1333~1336
Gray WS / 2005 / Use of solid phase extraction for improving HPLC assays of triterpene glycosides in gotu kola (Centella asiatica), parthenolide in feverfew (Tanacetum parthenium), and valerenic acids in valerian (Valeriana officinalis) / J Liq Chromatogr Relat Technol 28:581~592
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