지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The rate of metabolic syndrome (MetS) in women diagnosed as they age is one of the main concerns of health cares. Recently new strategies used to prevent progressions of MetS toward the diagnosis of diabetes have focused on plant flavonoids. This study was aimed to investigate the beneficial effects of flavonoids fraction of Mespilus germanica leaves (MGL) on MetS in ovariectomized (OVX) rats.Methods: Twenty-four adult female Wistar rats, weighing 200 to 250 g, were divided into 3 groups: Sham surgery, OVX + Salin, or OVX + Flavonoid. Three weeks after ovariectomy, animals displayed MetS criteria received flavonoid injection (10 mg/kg, intraperitoneally) for 21 days. Then the body weight, body mass index, waist circumference, visceral fat, fasting blood glucose, serum insulin, lipid profiles and tumor necrosis factor-α (TNF-α) were measured. Results: Treatment with flavonoids fraction of MGL significantly decreased serum level of insulin (P = 0.011), glucose (P = 0.024), TNF-α (P = 0.010), also MetS Z score (P = 0.020) and homeostasis model assessment of insulin resistance (P = 0.007). Lipid profiles and visceral fat showed insignificant reduction. Conclusions: Flavonoids of MGL attenuates some of the MetS components possibly via reduction in TNF-α inflammatory cytokine.
목차
등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Lau DCW. / 2011 / New insights in the prevention and early management of type 2 diabetes / Can J Diabetes 35:239~241
Kaur J. / 2014 / A comprehensive review on metabolic syndrome / Cardiol Res Pract 2014:943162
Janssen I / 2008 / Menopause and the metabolic syndrome: the Study of Women’s Health Across the Nation / Arch Intern Med 168:1568~1575
Arthur FK / 2013 / The prevalence of metabolic syndrome and its predominant components among pre-and postmenopausal Ghanaian women / BMC Res Notes 6:446
Tawfik SH / 2015 / Similar and additive effects of ovariectomy and diabetes on insulin resistance and lipid metabolism / Biochem Res Int 2015:567945
Kaur J. / 2014 / A comprehensive review on metabolic syndrome / Cardiol Res Pract 2014:943162
Janssen I / 2008 / Menopause and the metabolic syndrome: the Study of Women’s Health Across the Nation / Arch Intern Med 168:1568~1575
Arthur FK / 2013 / The prevalence of metabolic syndrome and its predominant components among pre-and postmenopausal Ghanaian women / BMC Res Notes 6:446
Tawfik SH / 2015 / Similar and additive effects of ovariectomy and diabetes on insulin resistance and lipid metabolism / Biochem Res Int 2015:567945
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