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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국식품영양과학회 Preventive Nutrition and Food Science Preventive Nutrition and Food Science Vol.24 No.3
- 발행연도
- 2019.9
- 수록면
- 274 - 282 (9page)
- DOI
- 10.3746/pnf.2019.24.3.274
이용수
초록· 키워드
오류제보하기
In this study we investigated the antidiabetic and antiobesity effects of aqueous ethanol extracts of traditional kochujang and doenjang. The average α-glucosidase inhibitory activity and adipogenesis inhibitory activity for the kochujang samples were 29.6% and 20.8%, respectively, while those of the doenjang samples were 46.3% and 11.6%, respectively. Therefore, antidiabetic activity is high in doenjang and antiobesity activity is high in kochujang. Kochujang and doenjang components responsible for suppressing the functional effects were investigated by metabolomic analysis. For kochujang, p-coumaric acid, N6,N6,N6-trimethyllysine, threonine, and methionine positively correlated with inhibition of adipogenesis activity, whereas for doenjang, betaine and betaine aldehyde were thought to be responsible for the antidiabetic effects. As p-coumaric acid and betaine were the most probable candidates with functional effects, these two compounds were selected for further analysis. Inhibition of adipogenesis was shown to be 14.0±1.85% for betaine chloride and 38.3 ±3.27% for p-coumaric acid, suggesting that p-coumaric acid is more effective than betaine against obesity. However, betaine exhibited higher α-glucosidase inhibitory activity than p-coumaric acid. Our results suggest that both kochujang and doenjang can be used against diabetes and obesity. However, clinical trials are necessary to support these results.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (47)
참고문헌 신청
American Diabetes Association / 2009 / Diagnosis and classification of diabetes mellitus / Diabetes Care 32:S62~S67
배초롱 / 2013 / 식이유도 비만 Mice에서 된장 및 무염된장의 항비만 효과 / 한국식품영양과학회지 42(7):1036~1042
Bhathena SJ / 2002 / Beneficial role of dietary phytoestrogens in obesity and diabetes / Am J Clin Nutr 76:1191~1201
Carlsen H / 2009 / Diet-induced obesity increases NF-B signaling in reporter mice / Genes Nutr 4:215~222
최기순 / 2009 / 한국 재래식 메주의 이화학적 및 미생물학적 특성 / 한국식품저장유통학회지 16(2):217~222
배초롱 / 2013 / 식이유도 비만 Mice에서 된장 및 무염된장의 항비만 효과 / 한국식품영양과학회지 42(7):1036~1042
Bhathena SJ / 2002 / Beneficial role of dietary phytoestrogens in obesity and diabetes / Am J Clin Nutr 76:1191~1201
Carlsen H / 2009 / Diet-induced obesity increases NF-B signaling in reporter mice / Genes Nutr 4:215~222
최기순 / 2009 / 한국 재래식 메주의 이화학적 및 미생물학적 특성 / 한국식품저장유통학회지 16(2):217~222
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