지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한치주과학회 Journal of Periodontal & Implant Science Journal of Periodontal & Implant Science 제49권 제4호
- 발행연도
- 2019.1
- 수록면
- 258 - 267 (10page)
이용수
초록· 키워드
오류제보하기
Purpose: Increased bone regeneration has been achieved through the use of stem cells in combination with graft material. However, the survival of transplanted stem cells remains a major concern. The purpose of this study was to evaluate the viability of transplanted mesenchymal stem cells (MSCs) at an early time point (24 hours) based on the type and form of the scaffold used, including type I collagen membrane and synthetic bone. Methods: The stem cells were obtained from the periosteum of the otherwise healthy dental patients. Four symmetrical circular defects measuring 6 mm in diameter were made in New Zealand white rabbits using a trephine drill. The defects were grafted with 1) synthetic bone (β-tricalcium phosphate/hydroxyapatite [β-TCP/HA]) and 1×105 MSCs, 2) collagen membrane and 1×105 MSCs, 3) β-TCP/HA+collagen membrane and 1×105 MSCs, or 4) β-TCP/HA, a chipped collagen membrane and 1×105 MSCs. Cellular viability and the cell migration rate were analyzed. Results: Cells were easily separated from the collagen membrane, but not from synthetic bone. The number of stem cells attached to synthetic bone in groups 1, 3, and 4 seemed to be similar. Cellular viability in group 2 was significantly higher than in the other groups (P<0.05). The cell migration rate was highest in group 2, but this difference was not statistically significant (P>0.05). Conclusions: This study showed that stem cells can be applied when a membrane is used as a scaffold under no or minimal pressure. When space maintenance is needed, stem cells can be loaded onto synthetic bone with a chipped membrane to enhance the survival rate.
목차
등록된 정보가 없습니다.
참고문헌 (38)
참고문헌 신청
Wang W / 2017 / Bone grafts and biomaterials substitutes for bone defect repair: a review / Bioact Mater 2:224~247
Tatsuya Kubota / 2017 / Regenerative capacity of augmented bone in rat calvarial guided bone augmentation model / Journal of Periodontal & Implant Science 47(2):77~85
Fernández-Domínguez M / 2019 / Can the macrogeometry of dental implants influence guided bone regeneration in buccal bone defects? Histomorphometric and biomechanical analysis in beagle dogs / J Clin Med 8:8
Ohta K / 2017 / Application of interconnected porous hydroxyapatite ceramic block for onlay block bone grafting in implant treatment: a case report / Exp Ther Med 14:5564~5568
Bertolai R / 2015 / Bone graft and mesenchimal stem cells:clinical observations and histological analysis / Clin Cases Miner Bone Metab 12:183~187
Tatsuya Kubota / 2017 / Regenerative capacity of augmented bone in rat calvarial guided bone augmentation model / Journal of Periodontal & Implant Science 47(2):77~85
Fernández-Domínguez M / 2019 / Can the macrogeometry of dental implants influence guided bone regeneration in buccal bone defects? Histomorphometric and biomechanical analysis in beagle dogs / J Clin Med 8:8
Ohta K / 2017 / Application of interconnected porous hydroxyapatite ceramic block for onlay block bone grafting in implant treatment: a case report / Exp Ther Med 14:5564~5568
Bertolai R / 2015 / Bone graft and mesenchimal stem cells:clinical observations and histological analysis / Clin Cases Miner Bone Metab 12:183~187
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Advanced Research on Stem Cell Therapy for Hepatic Diseases: Potential Implications of a Placenta-derived Mesenchymal Stem Cell-based Strategy
Hanyang Medical Reviews
2015 .01
-
Comparative characteristic study from bone marrow-derived mesenchymal stem cells
Journal of Veterinary Science
2021 .11
-
Adult Stem Cell Therapy for Stroke: Challenges and Progress
대한뇌졸중학회지
2016 .01
-
Effect of serum-derived albumin scaffold and canine adipose tissue-derived mesenchymal stem cells on osteogenesis in canine segmental bone defect model
Journal of Veterinary Science
2015 .12
-
Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)
생체재료학회지
2023 .03
-
Current perspectives in stem cell therapies for osteoarthritis of the knee
Journal of Yeungnam Medical Science
2020 .01
-
호흡기 질환에서의 중간엽 줄기 세포의 치료
대한내과학회지
2015 .01
-
Decellularized Non-cross-linked Collagen Membranes for Guided Bone Regeneration in Rabbit Calvarial Defects
Journal of Korean Dental Science
2022 .06
-
Eggshell membrane as a scaffold for the culture of mesenchymal stem cells
한국실험동물학회 학술발표대회 논문집
2021 .01
-
Recent advances in stem cell therapeutics and tissue engineering strategies
생체재료학회지
2018 .12
-
The effect of bacterial cellulose membrane compared with collagen membrane on guided bone regeneration
The Journal of Advanced of Prosthodontics
2015 .01
-
Applications of stem cells for curing pulmonary diseases
한국실험동물학회 학술발표대회 논문집
2018 .01
-
The advantages and limitations of mesenchymal stem cells in clinical application for treating human diseases
Osteoporosis and Sarcopenia
2018 .01
-
Clinical Trials of Adult Stem Cell Terapy in Patients with Ischemic Stroke
Journal of Clinical Neurology
2016 .01
-
Therapeutic Efficacy of Bone Marrow Derived Mesenchymal Stem Cells in Ototoxic Sensorineural Hearing Loss
대한이비인후-두경부외과학회지
2020 .01
-
Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells
Maxillofacial Plastic Reconstructive Surgery
2017 .03
-
Proliferation of equine bone marrow-derived mesenchymal stem cells in gelatin/β-tricalcium phosphate sponges
한국실험동물학회 학술발표대회 논문집
2017 .02
-
New types of guided bone regeneration membrane in alveolar bone defect of beagle dog
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Stem cell therapy in pain medicine
The Korean Journal of Pain
2019 .01
-
Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation
Biomolecules & Therapeutics(구 응용약물학회지)
2019 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0