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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제20권 제3호
- 발행연도
- 2019.1
- 수록면
- 58 - 64 (7page)
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초록· 키워드
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Sepsis is one of the systemic inflammatory responses, and it can cause acute respiratory distress syndrome (ARDS). Mechanical ventilation (MV) is one of the best treatments in patients with sepsis related to ARDS. However, mechanical ventilation itself can cause lung injury through various mechanisms. In this study, we applied mouse cecal ligation and puncture (CLP) model of sepsis with subsequent injurious ventilation to determine if sepsis could affect the development of ventilator-induced lung injury (VILI). To evaluate lung injury caused by sepsis, mild, moderate, and severe CLPs were induced. To evaluate lung injury caused by MV with or without sepsis, tidal volume (7 mL/kg, 10 mL/kg, or 24 mL/kg) was maintained for 3 h with or without septic insult (mild sepsis for 72 h). Lung compliance was then determined and biochemical evaluations were performed. Results showed that lung compliance was lower in the severe sepsis group compared to that in the mild or moderate sepsis group. MV alone decreased lung compliance in a tidal volume dependent manner. Both CLP and VILI groups showed significant decrease in lung compliance and increase in total cell count upon bronchoalveolar lavage fluid. These results confirm that ventilation can affect lung injury in mouse sepsis model.
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참고문헌 (21)
참고문헌 신청
Bhatia M / 2004 / Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome / J Pathol 202:145~156
Dixon DL / 2013 / Sepsis and ventilator-induced lung injury : an imperfect storm / Crit Care Med 41:354~355
Strieter RM / 1994 / Acute lung injury : the role of cytokines in the elicitation of neutrophils / J Investig Med 42:640~651
Fink MP / 2014 / Animal models of sepsis / Virulence 5:143~153
Fuller BM / 2013 / Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock : an observational study / Acad Emerg Med 20:659~669
Dixon DL / 2013 / Sepsis and ventilator-induced lung injury : an imperfect storm / Crit Care Med 41:354~355
Strieter RM / 1994 / Acute lung injury : the role of cytokines in the elicitation of neutrophils / J Investig Med 42:640~651
Fink MP / 2014 / Animal models of sepsis / Virulence 5:143~153
Fuller BM / 2013 / Mechanical ventilation and acute lung injury in emergency department patients with severe sepsis and septic shock : an observational study / Acad Emerg Med 20:659~669
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