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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 217 - 227 (11page)
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Production of therapeutic monoclonal antibodies (mAbs) using a plant platform has been considered an alternative to the mammalian cell-based production system. A plant-derived mAb CO17-1AK (mAbP COK) can specifically bind to various types of cancer cell lines. The target protein of mAbP COK is the epithelial cell adhesion molecule (EpCAM) highly expressed in human epithelial cancer cells, including breast and colorectal cancer cells. It has been hypothesized that its overexpression supports tumor growth and metastasis. A ganglioside is extended well beyond the surfaces of the various cell membranes and has roles in cell growth, inflammation, differentiation, and carcinogenesis. However, the regulation of EpCAM gene expression in breast cancers and the role of gangliosides in oncogenesis are unclear. Here, the purpose of this study was to determine the effects of mAbP COK on human breast cancer cell proliferation, apoptosis, and ganglioside expression patterns. Our results show that treatment with mAbP COK suppressed the growth of breast cancer cells and induced apoptotic cell death. It also upregulated the expression of metastasis-related gangliosides in breast cancer cells. Thus, treatment with mAbP COK may have chemo-preventive therapeutic effects against human breast cancer.
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참고문헌 (59)
참고문헌 신청
Ai-Haji M / 2003 / Prospective identification of tumorigenic breast cancer cells / Proc Natl Acad Sci U S A 100:3983~3988
Alfonso LF / 2009 / Aspirin inhibits camptothecininduced p21CIP1 levels and potentiates apoptosis in human breast cancer cells / Int J Oncol 34:597~608
Ariga T / 2008 / Role of ganglioside metabolism in the pathogenesis of Alzheimer’s disease-a review / J Lipid Res 49:1157~1175
Baeuerle PA / 2007 / EpCAM (CD326) finding its role in cancer / Br J Cacner 96:417~423
Balzar M / 1999 / The biology of the 17-1A antigen (Ep-CAM) / J Mol Med 77:699~712
Alfonso LF / 2009 / Aspirin inhibits camptothecininduced p21CIP1 levels and potentiates apoptosis in human breast cancer cells / Int J Oncol 34:597~608
Ariga T / 2008 / Role of ganglioside metabolism in the pathogenesis of Alzheimer’s disease-a review / J Lipid Res 49:1157~1175
Baeuerle PA / 2007 / EpCAM (CD326) finding its role in cancer / Br J Cacner 96:417~423
Balzar M / 1999 / The biology of the 17-1A antigen (Ep-CAM) / J Mol Med 77:699~712
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