지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 233 - 242 (10page)
- DOI
- 10.7841/ksbbj.2019.34.4.233
이용수
초록· 키워드
오류제보하기
Metallothionein (MT) protein consists of about 60 amino acids including 20 cysteine residues. MT as a lowmolecular weight intra-cellular protein is over-expressed in the cell exposed stressful conditions such as in the presence of heavy metals, starvation, heat, or inflammation. Recently, MT has been reported as an antioxidant proteins having an antioxidant effect to protect cells from oxidative stress by reactive oxygen species (ROS). Oxidative stress has been known as a cause of various diseases such as diabetes, diabetic complications and myocardial disease and has been also found to be associated with cancer. MT has potential as a therapeutic agent due to its excellent antioxidant effect and control of cell growth. Recombinant fusion metallothionein, which is fused a protein transduction domain or mitochondrial targeted domain into metallothionein, showed enhanced therapeutic effect. In addition, the expression of metallothionein was related anticancer drug sensitivity in the cancer cells and resistance. Because MT could control cell growth and survival, it is necessary to develop a therapeutic agent targeting MT. Therefore, we discussed the characteristics and therapeutic efficacy of metallothionein.
목차
Abstract
1. INTRODUCTION
2. 메탈로티오네인 단백질 치료제
3. 메탈로티오네인 유전자 치료제
4. CONCLUSION
REFERENCES
참고문헌 (74)
참고문헌 신청
Kagi, J. H. / 1991 / Overview of metallothionein / Method Enzymol 205:613~626
Capdevila, M. / 2011 / Metallothionein protein evolution:a miniassay / J Biol Inorg Chem 16:977~989
Viarengo, A. / 2000 / Antioxidant role of metallothioneins: a comparative overview / Cell Mol Biol 46:407~417
Liang, Q. / 2002 / Overexpression of metallothionein reduces diabetic cardiomyopathy / Diabetes 51:174~181
Dziegiel, P. / 2016 / Metallothioneins: Structure and Functions / Adv Anat Embryol Cel 218:3~20
Capdevila, M. / 2011 / Metallothionein protein evolution:a miniassay / J Biol Inorg Chem 16:977~989
Viarengo, A. / 2000 / Antioxidant role of metallothioneins: a comparative overview / Cell Mol Biol 46:407~417
Liang, Q. / 2002 / Overexpression of metallothionein reduces diabetic cardiomyopathy / Diabetes 51:174~181
Dziegiel, P. / 2016 / Metallothioneins: Structure and Functions / Adv Anat Embryol Cel 218:3~20
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UCI(KEPA) : I410-ECN-0101-2020-470-000264817