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논문 기본 정보
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- 학술저널
- 저자정보
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- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제30권 제6호
- 발행연도
- 2020.1
- 수록면
- 830 - 838 (9page)
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The histone-like nucleoid structuring protein (H-NS) is an abundant global regulator of environmentally controlled gene expression. Herein, we demonstrate that H-NS represses the expression of LeuO, the master regulator of the cyclic(Phe-Pro)-dependent signaling pathway, by directly binding to the upstream region of the gene. H-NS binds to a long stretched region (more than 160-bp long), which overlaps with binding sites for ToxR and LeuO. A high quantity of H-NS outcompetes ToxR for binding to the cis-acting element of leuO. However, our footprinting analyses suggests that the binding of H-NS is relatively weaker than LeuO or ToxR at the same molarity. Considering that the DNA nucleotide sequences of the upstream regions of leuO genes are highly conserved among various Vibrio, such patterns as those found in V. vulnificus would be a common feature in the regulation of leuO gene expression in Vibrionaceae. Taken together, these results suggest that, in species belonging to Vibrionaceae, H-NS regulates the expression of leuO as a basal stopper when cFP-ToxR mediated signaling is absent.
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참고문헌 (24)
참고문헌 신청
Picker MA / 2016 / H-NS, its family members and their regulation of virulence genes in Shigella species / Genes 7:112~126
Ghosh A / 2006 / Role of the histone-like nucleoid structuring protein in colonization, motility, and biledependent repression of virulence gene expression in Vibrio cholerae / Infect. Immun 74:3060~3064
Ayala JC / 2017 / H-NS : an overarching regulator of the Vibrio cholerae life cycle / Res. Microbiol 168:16~25
Nye MB / 2000 / Vibrio cholerae H-NS silences virulence gene expression at multiple steps in the ToxR regulatory cascade / J. Bacteriol 182:4295~4303
Park DK / 2006 / Cyclo(Phe-Pro)modulates the expression of ompU in Vibrio spp / J. Bacteriol 188:2214~2221
Ghosh A / 2006 / Role of the histone-like nucleoid structuring protein in colonization, motility, and biledependent repression of virulence gene expression in Vibrio cholerae / Infect. Immun 74:3060~3064
Ayala JC / 2017 / H-NS : an overarching regulator of the Vibrio cholerae life cycle / Res. Microbiol 168:16~25
Nye MB / 2000 / Vibrio cholerae H-NS silences virulence gene expression at multiple steps in the ToxR regulatory cascade / J. Bacteriol 182:4295~4303
Park DK / 2006 / Cyclo(Phe-Pro)modulates the expression of ompU in Vibrio spp / J. Bacteriol 188:2214~2221
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