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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 76 - 80 (5page)
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초록· 키워드
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Type 2 diabetes mellitus is a complex metabolic disorder associated with multiple genetic, developmental and environmental factors. The recent advances in gene expression microarray technologies as well as network-based analysis methodologies provide groundbreaking opportunities to study type 2 diabetes mellitus. In the present study, we used previously published gene expression microarray datasets of human skeletal muscle samples collected from 20 insulin sensitive individuals before and after insulin treatment in order to construct insulin-mediated regulatory network. Based on a motif discovery method implemented by iRegulon, a Cytoscape app, we identified 25 candidate regulons, motifs of which were enriched among the promoters of 478 up-regulated genes and 82 down-regulated genes. We then looked for a hierarchical network of the candidate regulators, in such a way that the conditional combination of their expression changes may explain those of their target genes. Using Genomica, a software tool for regulatory network construction, we obtained a hierarchical network of eight regulons that were used to map insulin downstream signaling network. Taken together, the results illustrate the benefits of combining completely different methods such as motif-based regulatory factor discovery and expression level-based construction of regulatory network of their target genes in understanding insulin induced biological processes and signaling pathways.
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참고문헌 (19)
참고문헌 신청
Cline GW. / 1999 / Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes / N Engl J Med 341:240~246
Pollack JR. / 1999 / Genome-wide analysis of DNA copy-number changes using cDNA microarrays / Nat Genet 23:41~46
Krylov AS. / 2001 / Massive parallel analysis of the binding specificity of histone-like protein HU to single-and double-stranded DNA with generic oligodeoxyribonucleotide microchips / Nucleic Acids Res 29:2654~2660
Mutarelli M. / 2008 / Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells / BMC Bioinformatics. 9(Suppl 2):S12
Wu X. / 2007 / The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle / Endocrine 31:5~17
Pollack JR. / 1999 / Genome-wide analysis of DNA copy-number changes using cDNA microarrays / Nat Genet 23:41~46
Krylov AS. / 2001 / Massive parallel analysis of the binding specificity of histone-like protein HU to single-and double-stranded DNA with generic oligodeoxyribonucleotide microchips / Nucleic Acids Res 29:2654~2660
Mutarelli M. / 2008 / Time-course analysis of genome-wide gene expression data from hormone-responsive human breast cancer cells / BMC Bioinformatics. 9(Suppl 2):S12
Wu X. / 2007 / The effect of insulin on expression of genes and biochemical pathways in human skeletal muscle / Endocrine 31:5~17
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