지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제24권 제4호
- 발행연도
- 2020.1
- 수록면
- 311 - 317 (7page)
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초록· 키워드
오류제보하기
In the present experimental study, cecal ligation and puncture significantly increased the myocardial injury assessed in terms of excess release of creative kinase-MB (CK-MB), cardiac troponin I (cTnI), interleukin (IL)-6 and decrease of IL-10 in the blood following 12 h of laparotomy procedure as compared to normal control. Also, a significant increase in protein expression levels of high-mobility group box 1 (HMGB1) and decreased phosphorylation of glycogen synthase kinase-3β (GSK-3β) was observed in the myocardial tissue as compared to normal control. A single independent administration of telmisartan (2 and 4 mg/kg) and AR-A014418 (1 and 2 mg/kg) substantially reduced sepsis-induced myocardial injury in terms of decrease levels of CK-MB, cTnI and IL-6, HMGB1, GSK-3β and increase in IL-10 and p-GSK-3β in the blood in sepsis- subjected rats. The effects of telmisartan at dose 4 mg/kg and AR-A014418 at a dose of 2 mg/kg were significantly higher than the telmisartan at a dose of 2 mg/kg and AR-A014418 1 mg/kg respectively. Further, no significant effects on different parameters were observed in the sham control group in comparison to normal. Therefore it is plausible to suggest that sepsis may increase the levels of angiotensin II to trigger GSK-3β-dependent signaling to activate the HMGB1/receptors for advanced glycation end products, which may promote inflammation and myocardial injury in sepsis-subjected rats.
목차
등록된 정보가 없습니다.
참고문헌 (27)
참고문헌 신청
Sagy M / 2013 / Definitions and pathophysiology of sepsis / Curr Probl Pediatr Adolesc Health Care 43:260~263
Walley KR / 2018 / Sepsis-induced myocardial dysfunction / Curr Opin Crit Care 24:292~299
Wang Z / 2019 / Alleviation of sepsis‑induced cardiac dysfunction by overexpression of Sestrin2 is associated with inhibition of p‑S6K and activation of the p‑AMPK pathway / Mol Med Rep 20:2511~2518
Angus DC / 2001 / Epidemiology of severe sepsis in the United States : analysis of incidence, outcome, and associated costs of care / Crit Care Med 29:1303~1310
Sifi A / 2017 / Role of angiotensin II and angiotensin type-1 receptor in scorpion venom-induced cardiac and aortic tissue inflammation / Exp Mol Pathol 102:32~40
Walley KR / 2018 / Sepsis-induced myocardial dysfunction / Curr Opin Crit Care 24:292~299
Wang Z / 2019 / Alleviation of sepsis‑induced cardiac dysfunction by overexpression of Sestrin2 is associated with inhibition of p‑S6K and activation of the p‑AMPK pathway / Mol Med Rep 20:2511~2518
Angus DC / 2001 / Epidemiology of severe sepsis in the United States : analysis of incidence, outcome, and associated costs of care / Crit Care Med 29:1303~1310
Sifi A / 2017 / Role of angiotensin II and angiotensin type-1 receptor in scorpion venom-induced cardiac and aortic tissue inflammation / Exp Mol Pathol 102:32~40
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