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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제18권 제2호
- 발행연도
- 2020.1
- 수록면
- 241 - 248 (8page)
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초록· 키워드
오류제보하기
Objective: Alzheimer’s disease is a popular neurodegenerative disorder which is growing in the elderly people. Exposure to environmental pollutant like aluminum could trigger or accelerate its involved mechanisms like tau phosphorylation. The current study will evaluate the effect of alone or co-administration of Citicoline or/and magnesium on the aluminum chloride induced memory impairment. Methods: Male albino mice were randomly divided into different groups (n = 7). Memory impairment was induced via orally administration of 300 mg/kg Aluminum Chloride for 28 days. Based on respective group, animals received 100, 250, 500 mg/kg of Citicoline or 50, 100, 150 mg/kg of Magnesium sulfate (MgSO4), intraperitoneally. In co-administration, 50 mg/kg of MgSO4 injected concomitantly with 100, 250, or 500 mg/kg of Citicoline. Rivastigmine (2 mg/kg intraperitoneally) was used as a positive control. Memory was evaluated using the Object Recognition Task (ORT) and Passive Avoidance Test (PAT). Results: The studied doses of Citicoline or MgSO4 when administered individually showed significant increase in the discrimination index in ORT and latency time in the PAT compared to the Aluminium chloride (AlCl3) treated group. Concomitant injection of 50 mg/kg MgSO4 with the different doses of Citicoline strongly increased the above indices values in comparison to each alone. Conclusion: The findings show, individual administration of Citicoline or MgSO4 inverted the AlCl3-induced memory impairment in a dose independent manner. The addition of MgSO4 to the Citicoline showed a synergistic effect in the PAT and likely additive effect in the ORT.
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등록된 정보가 없습니다.
참고문헌 (35)
참고문헌 신청
Ishrat T / 2009 / Selenium prevents cognitive decline and oxidative damage in rat model of streptozotocin-induced experimental dementia of Alzheimer’s type / Brain Res 1281:117~127
Area-Gomez E / 2017 / On the pathogenesis of Alzheimer’s disease : the MAM hypothesis / FASEB J 31:864~867
Sayad Kocahan / 2017 / Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors / Clinical Psychopharmacology and Neuroscience 15(1):1~8
Huang Y / 2018 / Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer’s disease mice / CNS Neurosci Ther 24:70~79
Hampel H / 2018 / The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease / Brain 141:1917~1933
Area-Gomez E / 2017 / On the pathogenesis of Alzheimer’s disease : the MAM hypothesis / FASEB J 31:864~867
Sayad Kocahan / 2017 / Mechanisms of Alzheimer’s Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors / Clinical Psychopharmacology and Neuroscience 15(1):1~8
Huang Y / 2018 / Magnesium boosts the memory restorative effect of environmental enrichment in Alzheimer’s disease mice / CNS Neurosci Ther 24:70~79
Hampel H / 2018 / The cholinergic system in the pathophysiology and treatment of Alzheimer’s disease / Brain 141:1917~1933
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