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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 347 - 355 (9page)
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초록· 키워드
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Cognitive impairment is considered to be key research topics in the field of neurodegenerative diseases and in understanding of learning and memory. In the present study, we investigated neuroprotective effects of Schisandra chinensis (SC) and Ribes fasciculatum (RF) extracts in hydrogen peroxide-induced neuronal cell death in vitro and scopolamine-induced cognitive impairment in Sprague Dawley® (SD) rat in vivo. Apoptotic cell death in neuroblastic PC12 cell line was induced by hydrogen peroxide for 1 hour at 100 μM. However, mixture of SC and RF treatment prevented peroxide induced PC12 cell death with no neurotoxic effects. For in vivo experiment, the effect of SC and RF extracts on scopolamine-induced cognitive impairment in SD rat was evaluated by spontaneous alternation behavior in Y-Maze test. After 30 min scopolamine injection, the scopolamine-induced rats presented significantly decreased % spontaneous alteration and acetylcholine level, compared to non-induced group. However, treatment of SC+RF extracts rescued the reduced % spontaneous alteration with acetylcholine concentration from hippocampus in scopolamine- induced rats. These results suggested that mixture of SC and RF extract may be a potential natural therapeutic agent for the prevention of cognitive impairment. Key words: Schisandra chinensis, Ribes fasciculatum, scopolamine-induced rat, neuroprotection, oxidative stress
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참고문헌 (39)
참고문헌 신청
Bartus RT / 1982 / The cholinergic hypothesis of geriatric memory dysfunction / Science 217:408~414
Brand JJ / 1966 / Drugs used in motion sickness. A critical review of the methods available for the study of drugs of potential value in its treatment and of the information which has been derived by these methods / Pharmacol Rev 18:895~924
Byun SN. / 2010 / Effects of mixed extracts of Chenwhangbosimdan and Curcuma longa L. on memory and antioxidant enzyme activities in intracerebroventricular amyloid β-injected Alzheimer's disease model rat
Canal N / 1996 / Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer's disease / Clin Pharmacol Ther 60:218~228
조영수 / 2016 / 칼슘 배합 비율에 따른 초석잠의 scopolamine 치매유도 흰쥐에 대한 기억손상 개선 효과 / 생명과학회지 26(7):812~818
Brand JJ / 1966 / Drugs used in motion sickness. A critical review of the methods available for the study of drugs of potential value in its treatment and of the information which has been derived by these methods / Pharmacol Rev 18:895~924
Byun SN. / 2010 / Effects of mixed extracts of Chenwhangbosimdan and Curcuma longa L. on memory and antioxidant enzyme activities in intracerebroventricular amyloid β-injected Alzheimer's disease model rat
Canal N / 1996 / Relationship between pharmacodynamic activity and cognitive effects of eptastigmine in patients with Alzheimer's disease / Clin Pharmacol Ther 60:218~228
조영수 / 2016 / 칼슘 배합 비율에 따른 초석잠의 scopolamine 치매유도 흰쥐에 대한 기억손상 개선 효과 / 생명과학회지 26(7):812~818
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