지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 742 - 750 (9page)
이용수
초록· 키워드
오류제보하기
Purpose: Muscle mass, strength, and composition determine muscle quantity and quality. However, data on muscle propertiesin relation to bone mass or insulin resistance are limited in Asian populations. This study aimed to investigate the relative importanceof muscle measurements in regards to their relationship with lower bone mass and insulin resistance. Materials and Methods: In this study, 192 postmenopausal women (age, 72.39±6.07 years) were enrolled. We measured musclecross-sectional area (CSA) and attenuation at the gluteus maximus and quadriceps muscles through quantitative computed tomography. Muscle strength and physical performance were evaluated with the hand grip test and Short Physical PerformanceBattery (SPPB). Pearson correlation analysis and linear regression were performed to evaluate the relationship between muscleproperties and homeostatic model assessment-insulin resistance (HOMA-IR) or bone mineral density (BMD). Results: Muscle CSA, hand grip strength, and SPPB score held positive correlations with spine and hip BMDs, but not with insulinresistance. In contrast, muscle attenuation of the gluteus maximus or quadriceps was inversely related to HOMA-IR (r=-0.194,p=0.018 and r=-0.292, p<0.001, respectively), but not BMD. Compared with the control group, muscle CSA was significantly decreasedin patients with osteoporosis; however, decreased muscle attenuation, indicating high fat infiltration, was found only inpatients with diabetes. Conclusion: Muscle mass, strength, and physical performance were associated with low bone mass, and accumulation of intramuscularfat, a histological hallmark of persistently damaged muscles, may play a major role in the development of insulin resistancein Korean postmenopausal women.
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참고문헌 (30)
참고문헌 신청
Kim KJ / 2012 / Aortic calcification and bone metabolism : the relationship between aortic calcification, BMD, vertebral fracture, 25-hydroxyvitamin D, and osteocalcin / Calcif Tissue Int 91:370~378
Lang TF / 2002 / Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures / Bone 30:247~250
Ochi M / 2010 / Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population / Geriatr Gerontol Int 10:233~243
Kim TN / 2013 / Body size phenotypes and low muscle mass : the Korean Sarcopenic Obesity Study(KSOS) / J Clin Endocrinol Metab 98:811~817
임수 / 2014 / Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk / Endocrinology and Metabolism 29(1):1~4
Lang TF / 2002 / Measurement of bone mineral density at the spine and proximal femur by volumetric quantitative computed tomography and dual-energy X-ray absorptiometry in elderly women with and without vertebral fractures / Bone 30:247~250
Ochi M / 2010 / Quadriceps sarcopenia and visceral obesity are risk factors for postural instability in the middle-aged to elderly population / Geriatr Gerontol Int 10:233~243
Kim TN / 2013 / Body size phenotypes and low muscle mass : the Korean Sarcopenic Obesity Study(KSOS) / J Clin Endocrinol Metab 98:811~817
임수 / 2014 / Ectopic Fat Assessment Focusing on Cardiometabolic and Renal Risk / Endocrinology and Metabolism 29(1):1~4
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