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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 충북대학교 동물의학연구소 Journal of Biomedical and Translational Research Journal of Biomedical and Translational Research 제20권 제4호
- 발행연도
- 2019.1
- 수록면
- 75 - 81 (7page)
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초록· 키워드
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Selectins are cell membrane glycoproteins that recognize specific glycoconjugates expressed on the surface of cells. Then, selectins adjust cell-cell interactions that are important in inflammation, hemostasis and cancer metastasis. Selectins mediate leukocyte calls to move into the site of inflammation through interactions with activated endothelial cells or endogenous selectin ligands expressed in high endothelial venules. Types of selectins are divided into L-selectin, E-selectin and P-selectin, which are called to CD62L, CD62E, and CD62P, respectively. Each selectin is composed of four regions; the C-type lectin region of N-terminal, the epidermal growth factor (EGF) region, the intracellular C-terminal region, and the hydrophobic transmembrane region. They have similar structures but differ in their binding specificities and tissue distributions. The selectin family commonly recognizes the sialyl Lewis X (sLeX) on carbohydrate structures. Although biological ligands bound to each selectin are different from each other, they commonly bind to P-selectin glycoprotein ligand-1 (PSGL-1) ligand. The PSGL-1 ligand is a glycoprotein promoting cell adhesion in inflammatory responses. If the absence of selectins and their ligands in humans and animals are, should lead to persistent infections and diseases. Selectin family must be considered as a key subject for drug discovery since they have various functions depending on the ligand which they bind to.
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참고문헌 (40)
참고문헌 신청
Medzhitov R / 2008 / Origin and physiological roles of inflammation / Nature 454:428~435
Yago T / 2010 / E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling / Blood 116:485~494
McEver RP / 2015 / Selectins : initiators of leucocyte adhesion and signalling at the vascular wall / Cardiovasc Res 107:331~339
Goodison S / 1999 / CD44 cell adhesion molecules / Mol Pathol 52:189~196
Borsig L / 2018 / Selectins in cancer immunity / Glycobiology 28:648~655
Yago T / 2010 / E-selectin engages PSGL-1 and CD44 through a common signaling pathway to induce integrin alphaLbeta2-mediated slow leukocyte rolling / Blood 116:485~494
McEver RP / 2015 / Selectins : initiators of leucocyte adhesion and signalling at the vascular wall / Cardiovasc Res 107:331~339
Goodison S / 1999 / CD44 cell adhesion molecules / Mol Pathol 52:189~196
Borsig L / 2018 / Selectins in cancer immunity / Glycobiology 28:648~655
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