지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 427 - 437 (11page)
이용수
초록· 키워드
오류제보하기
Purpose: We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. Materials and Methods: The microsatellite instability status of resected early gastric tumors was evaluated using two mononucleotide repeat markers (BAT25 and BAT26) and three dinucleotide repeat markers (D5S346, D2S123, and D17S250). Tumors with instability in two or more markers were defined as microsatellite instability-high (MSI-H) and others were classified as microsatellite stable (MSS). Results: Overall, 1,156 tumors were included in the analysis, with 85 (7.4%) classified as MSI-H compared with MSS tumors. For MSI-H tumors, there was a significant correlation with the female sex, older age, tumor location in the lower gastric body, intestinal histology, lymphovascular invasion (LVI), and submucosal invasion (P<0.05). There was also a trend toward an association with lymph node (LN) metastasis (P=0.056). In mucosal gastric cancer, there was no significant difference in MSI status in tumors with LN metastasis or tumors with LVI. In submucosal gastric cancer, LVI was more frequently observed in MSI-H than in MSS tumors (38.9% vs. 25.0%, P=0.027), but there was no difference in the presence of LN metastases. The prognosis of MSI-H tumors was similar to that of MSS tumors (log-rank test, P=0.797, the hazard ratio for MSI-H was adjusted by age, sex, pT stage, and the number of metastatic LNs, 0.932; 95% confidence interval, 0.423–2.054; P=0.861). Conclusions: MSI status was not useful in predicting prognosis in early gastric cancer. However, the frequent presence of LVI in early MSI-H gastric cancer may help guide the appropriate treatment for patients, such as endoscopic treatment or limited LN surgical dissection.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108
정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316
Sugano K / 2015 / Screening of gastric cancer in Asia / Best Pract Res Clin Gastroenterol 29:895~905
Nakagawa M / 2015 / Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study / BMC Cancer 15:943
Lai JF / 2009 / Prediction of recurrence of early gastric cancer after curative resection / Ann Surg Oncol 16:1896~1902
정규원 / 2018 / Cancer Statistics in Korea: Incidence, Mortality, Survival, and Prevalence in 2015 / Cancer Research and Treatment 50(2):303~316
Sugano K / 2015 / Screening of gastric cancer in Asia / Best Pract Res Clin Gastroenterol 29:895~905
Nakagawa M / 2015 / Difficulty of predicting the presence of lymph node metastases in patients with clinical early stage gastric cancer: a case control study / BMC Cancer 15:943
Lai JF / 2009 / Prediction of recurrence of early gastric cancer after curative resection / Ann Surg Oncol 16:1896~1902
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Usefulness of Immunohistochemistry for Microsatellite Instability Screening in Gastric Cancer
Gut and Liver
2015 .01
-
Microsatellite Instability of Gastric and Colorectal Cancers as a Predictor of Synchronous Gastric or Colorectal Neoplasms
Gut and Liver
2016 .01
-
Adjuvant Chemotherapy in Microsatellite Instability-High Gastric Cancer
Cancer Research and Treatment
2020 .01
-
Microsatellite instability and the effectiveness of adjuvant treatment in pT1N1 gastric cancer: A multi-cohort study
대한임상종양학회 학술대회지
2021 .06
-
Prognostic Impact of Microsatellite Instability in Colorectal Cancer Presenting With Mucinous, Signet-Ring, and Poorly Differentiated Cells
Annals of Coloproctology
2016 .01
-
Clinical Utility of a Fully Automated Microsatellite Instability Test with Minimal Hands-on Time
Journal of Pathology and Translational Medicine
2019 .01
-
Sporadic Early Onset Colorectal Cancer in Pakistan: a Case-Control Analysis of Microsatellite Instability
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Clinical Implications of Microsatellite Instability in T1 Colorectal Cancer
Yonsei Medical Journal
2015 .01
-
Single Patient Classifier Assay, Microsatellite Instability, and Epstein-Barr Virus Status Predict Clinical Outcomes in Stage II/III Gastric Cancer: Results from CLASSIC Trial
Yonsei Medical Journal
2019 .01
-
Frequency of Mismatch Repair Deficiency/High Microsatellite Instability and Its Role as a Predictive Biomarker of Response to Immune Checkpoint Inhibitors in Gynecologic Cancers
Cancer Research and Treatment
2022 .10
-
Which Clinicopathological Factors Are Related to Tumor Size in Papillary Thyroid Cancer?
The Journal of Endocrine Surgery
2019 .01
-
The Necessity of Guidance: Optimizing Adjuvant Therapy for Stage II/III MSI-H Gastric Cancer Through the Interplay of Evidence, Clinical Judgment, and Patient Preferences
Journal of Gastric Cancer
2024 .07
-
A Multi-cohort Study of the Prognostic Significance of Microsatellite Instability or Mismatch Repair Status after Recurrence of Resectable Gastric Cancer
Cancer Research and Treatment
2020 .01
-
Clinical implication of adjuvant chemotherapy according to mismatch repair status in patients with intermediate-risk stage II colon cancer: a retrospective study
Journal of Yeungnam Medical Science
2022 .04
-
Differences in Prevalence of Lymphovascular Invasion among Early Gastric Cancers between Korea and Japan
Gut and Liver
2017 .01
-
Microsatellite Instability Status of Interval Colorectal Cancers in a Korean Population
Gut and Liver
2016 .01
-
Gastric Cancer
대한외과학회 학술대회 초록집
2022 .11
-
Hypomethylation of LINE-1 and Gastric Cancer LN Metastasis
대한임상종양학회 학술대회지
2016 .02
-
A Rare Case of Lymph Node Metastasis from Early Gastric Cancer
Clinical Endoscopy
2019 .01
-
Relation between Tumor Diameter to Depth of Submucosal Invasion as a Surrogate Marker for Tumor Aggressiveness in Early Gastric Cancer
대한임상종양학회 학술대회지
2016 .02
이 논문의 저자 정보
최근 본 자료
댓글(0)
0