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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 14 - 20 (7page)
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Despite the importance of mutation rate, some difficulties exist in estimating it. Next-generation sequencing (NGS) data yields large numbers of single-nucleotide polymorphisms, which can make it feasible to estimate substitution rates. The genetic substitution rates of Hanwoo and Holstein cattle were estimated using NGS data. Our main findings was to calculate the gene's substitution rates. Through estimation of genetic substitution rates, we found: diving region of altered substitution density exists. This region may indicate a boundary between protected and unprotected genes. The protected region is mainly associated with the gene ontology terms of regulatory genes. The genes that distinguish Hanwoo from Holstein in terms of substitution rate predominantly have gene ontology terms related to blood and circulatory system. This might imply that Hanwoo and Holstein evolved with dissimilar mutation rates and processes after domestication. The difference in meat quality between Hanwoo and Holstein could originate from differential evolution of the genes related to these blood and circulatory system ontology terms.
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등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Kumar S / 2002 / Mutation rates in mammalian genomes / Proc Natl Acad Sci U S A 99:803~808
Lee KT / 2013 / Whole-genome resequencing of Hanwoo (Korean cattle) and insight into regions of homozygosity / BMC Genomics 14:519
Hailu Dadi Melka / 2011 / Identification of Genomic Differences between Hanwoo and Holstein Breeds Using the Illumina Bovine SNP50 BeadChip / Genomics & Informatics 9(2):69~73
Lee HJ / 2014 / Deciphering the genetic blueprint behind Holstein milk proteins and production / Genome Biol Evol 6:1366~1374
Rhee MS / 2000 / Combination of low voltage electrical stimulation and early postmortem temperature conditioning on degradation of myofibrillar proteins in Korean native cattle (Hanwoo) / Meat Sci 55:391~396
Lee KT / 2013 / Whole-genome resequencing of Hanwoo (Korean cattle) and insight into regions of homozygosity / BMC Genomics 14:519
Hailu Dadi Melka / 2011 / Identification of Genomic Differences between Hanwoo and Holstein Breeds Using the Illumina Bovine SNP50 BeadChip / Genomics & Informatics 9(2):69~73
Lee HJ / 2014 / Deciphering the genetic blueprint behind Holstein milk proteins and production / Genome Biol Evol 6:1366~1374
Rhee MS / 2000 / Combination of low voltage electrical stimulation and early postmortem temperature conditioning on degradation of myofibrillar proteins in Korean native cattle (Hanwoo) / Meat Sci 55:391~396
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