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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 49 - 56 (8page)
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To determine the protective effect of aloe-emodin (AE) from high glucose induced toxicity in RIN-5F (pancreatic ${\beta}$-cell) cell and restoration of its function was analyzed. RIN-5F cells have been cultured in high glucose (25 mM glucose) condition, with and without AE treatment. RIN-5F cells cultured in high glucose decreased cell viability and increased ROS levels after 48 hr compared with standard medium (5.5 mM glucose). Glucotoxicity was confirmed by significantly increased ROS production, increased pro-inflammatory (IFN-${\gamma}$, IL-$1{\beta}$,) & decreased anti-inflammatory (IL-6&IL-10) cytokine levels, increased DNA fragmentation. In addition, we found increased Bax, caspase 3, Fadd, and Fas and significantly reduced Bcl-2 expression after 48 hr. RIN-5F treated with both high glucose and AE ($20{\mu}M$) decreased ROS generation and prevent RIN-5F cell from glucotoxicity. In addition, AE treated cells cultured in high glucose were transferred to standard medium, normal responsiveness to glucose was restored within 8hr and normal basal insulin release within 24 hr was achieved when compared to high glucose.
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참고문헌 (33)
참고문헌 신청
Anand, S / 2010 / Aloe emodin glycosides stimulate glucose transport and glycogen storage through PI3K dependent mechanism in L6 myotubes and inhibits adipocyte differentiation in 3T3L1 adipocytes / FEBS Lett 584:3170~3178
Baines, C. P / 2005 / Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death / Nature 434:658~662
Bernard, C / 1999 / Neogenesis vs. apoptosis as main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats / FASEB J 13:1195~1205
Chen, H. C / 2004 / Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promy elocytic leukemia HL-60 cells / Food Chem. Toxicol 42:1251~1257
Donath, M. Y / 2001 / Hyperglycemia induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes / Diabetes 48:738~744
Baines, C. P / 2005 / Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death / Nature 434:658~662
Bernard, C / 1999 / Neogenesis vs. apoptosis as main components of pancreatic beta cell ass changes in glucose-infused normal and mildly diabetic adult rats / FASEB J 13:1195~1205
Chen, H. C / 2004 / Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promy elocytic leukemia HL-60 cells / Food Chem. Toxicol 42:1251~1257
Donath, M. Y / 2001 / Hyperglycemia induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes / Diabetes 48:738~744
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