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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 395 - 401 (7page)
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Endochondral bone formation is the process by which mesenchymal cells condense into chondrocytes, which are ultimately responsible for new bone formation. The processes of chondrogenic differentiation and hypertrophy are critical for bone formation and are therefore highly regulated. The present study was designed to investigate the effect of aloe-emodin on chondrogenic differentiation in clonal mouse chondrogenic ATDC5 cells. Aloe-emodin treatment stimulated the accumulation of cartilage nodules in a dose-dependent manner. ATDC5 cells were treated with aloe-emodin and stained with alcian blue. Compared with the control cells, the ATDC5 cells showed more intense alcian blue staining. This finding suggested that aloe-emodin induced the synthesis of matrix proteoglycans and increased the activity of alkaline phosphatase. Aloe-emodin also enhanced the expressions of chondrogenic marker genes such as collagen II, collagen X, BSP and RunX2 in a time-dependent manner. Furthermore, examination of the MAPK signaling pathway showed that aloe-emodin increased the activation of extracellular signal-regulated kinase (ERK), but had no effect on p38 and c-jun N-terminal kinase (JNK). Aloe-emodin also enhanced the protein expression of BMP-2 in a time-dependent manner. Thus, these results showed that aloe-emodin exhibited chodromodulating effects via the BMP-2 or ERK signaling pathway. Aloe-emodin may have potential future applications for the treatment of growth disorders.
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참고문헌 (32)
참고문헌 신청
Akiyama, H / 2000 / Differential expressions of BMP family genes during chondrogenic differentiation of mouse ATDC5 cells / Cell Struct. Funct 25:195~204
Bobick, B. E / 2007 / Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEKERK activation / J. Cell Physiol 211:233~243
Choi, H. J / 2011 / Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin / Eur. J. Pharmacol 655:9~15
Davis, R. J / 2000 / Signal transduction by the JNK group of MAP kinases / Cell 103:239~252
Huang, Q / 2005 / Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway / Cell. Mol. Life Sci 62:1167~1175
Bobick, B. E / 2007 / Fibroblast growth factors 2, 4, and 8 exert both negative and positive effects on limb, frontonasal, and mandibular chondrogenesis via MEKERK activation / J. Cell Physiol 211:233~243
Choi, H. J / 2011 / Stimulation of chondrogenesis in ATDC5 chondroprogenitor cells and hypertrophy in mouse by Genkwadaphnin / Eur. J. Pharmacol 655:9~15
Davis, R. J / 2000 / Signal transduction by the JNK group of MAP kinases / Cell 103:239~252
Huang, Q / 2005 / Emodin inhibits tumor cell migration through suppression of the phosphatidylinositol 3-kinase-Cdc42/Rac1 pathway / Cell. Mol. Life Sci 62:1167~1175
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