메뉴 건너뛰기
.. 내서재 .. 알림
소속 기관/학교 인증
인증하면 논문, 학술자료 등을  무료로 열람할 수 있어요.
한국대학교, 누리자동차, 시립도서관 등 나의 기관을 확인해보세요
(국내 대학 90% 이상 구독 중)
로그인 회원가입 고객센터 ENG
주제분류
인문학
인문학 일반 역사학 철학 종교학 어문학 기타 인문학
사회과학
사회과학 일반 경영학 관광학 교육학 군사학 문헌정보학 법학 사회학 신문방송학 심리과학 정치외교학 지리학 행정학 경제학 무역학 인류학 기타 사회과학
자연과학
자연과학 일반 물리학 생물학 생활과학 수학·통계학 천문학 지구과학 화학 기타 자연과학
공학
공학 일반 건축공학 기계공학 산업공학 재료·에너지공학 전기전자공학 조선해양공학 화학공학 컴퓨터학 기타공학
의약학
의학 일반 간호학 수의학 약학 한의학 기초의학 임상의학 기타 의약학
농수해양학
농수해양학 일반 농학 수산학 식품과학 임학 축산학 해상운송학 기타 농수해양학
예술체육학
예술 일반 디자인 미술 미용 사진 음악학 의상 체육 공연매체예술 기타 예술체육학
복합학
학제간연구 과학기술학 뇌인지과학 기술정책 기타 복합학

ENG

추천
검색

논문 기본 정보

자료유형
학술저널
저자정보
Gwak, Ho-Shin (Department of System Cancer Science, Graduate School of Cancer Science and Policy) Lee, Sang Hyun (Department of Diagnostic Radiology, National Cancer Center) Park, Weon Seo (Department of Pathology, National Cancer Center) Shin, Sang Hoon (Department of Neuro-Oncology Clinic, National Cancer Center) Yoo, Heon (Department of Neuro-Oncology Clinic, National Cancer Center) Lee, Seung Hoon (Department of Neuro-Oncology Clinic, National Cancer Center)
저널정보
대한신경외과학회 대한신경외과학회지 대한신경외과학회지 제58권 제1호
발행연도
2015.1
수록면
1 - 8 (8page)

이용수

표지
📌
연구주제
📖
연구배경
🔬
연구방법
🏆
연구결과
AI에게 요청하기
추천
검색

초록· 키워드

오류제보하기
Treatment of Leptomeningeal carcinomatosis (LMC) from solid cancers has not advanced noticeably since the introduction of intra-cerebrospinal fluid (CSF) chemotherapy in the 1970's. The marginal survival benefit and difficulty of intrathecal chemotherapy injection has hindered its wide spread use. Even after the introduction of intraventricular chemotherapy with Ommaya reservoir, frequent development of CSF flow disturbance, manifested as increased intracranial pressure (ICP), made injected drug to be distributed unevenly and thus, the therapy became ineffective. Systemic chemotherapy for LMC has been limited as effective CSF concentration can hardly be achieved except high dose methotrexate (MTX) intravenous administration. However, the introduction of small molecular weight target inhibitors for primary cancer treatment has changed the old concept of 'blood-brain barrier' as the ultimate barrier to systemically administered drugs. Conventional oral administration achieves an effective concentration at the nanomolar level. Furthermore, many studies report that a combined treatment of target inhibitor and intra-CSF chemotherapy significantly prolongs patient survival. Ventriculolumbar perfusion (VLP) chemotherapy has sought to increase drug delivery to the subarachnoid CSF space even in patients with disturbed CSF flow. Recently authors performed phase 1 and 2 clinical trial of VLP chemotherapy with MTX, and 3/4th of patients with increased ICP got controlled ICP and the survival was prolonged. Further trials are required with newly available drugs for CSF chemotherapy. Additionally, new LMC biologic/pharmacodynamic markers for early diagnosis and monitoring of the treatment response are to be identified with the help of advanced molecular biology techniques.
#Cancer #Cerebrospinal fluid #Chemotherapy #Leptomeningeal carcinomatosis #Lumbar #Ventricle

목차

등록된 정보가 없습니다.

참고문헌 (69)

참고문헌 신청
Balis FM. / 2000 / Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration / Cancer Chemother Pharmacol 45:259~264 google schola Baraniskin A. / 2012 / MicroRNAs in cerebrospinal fluid as biomarker for disease course monitoring in primary central nervous system lymphoma / J Neurooncol 109:239~244 google schola Bernardi RJ. / 2008 / Phase I clinical trial of intrathecal gemcitabine in patients with neoplastic meningitis / Cancer Chemother Pharmacol 62:355~361 google schola Blaney SM. / 2005 / Intrathecal mafosfamide : a preclinical pharmacology and phase I trial / J Clin Oncol 23:1555~1563 google schola Blaney SM. / 2005 / Phase I clinical trial of mafosfamide in infants and children aged 3 years or younger with newly diagnosed embryonal tumors : a pediatric brain tumor consortium study(PBTC-001) / J Clin Oncol 23:525~531 google schola

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!

이 논문의 저자 정보

최근 본 자료

전체보기

댓글(0)

0