지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 29 - 39 (11page)
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Objectives: There is still no consensus on the optimal treatment for primary gastrointestinal lymphoma (PGIL). The aim of this study was to compare surgery combined with chemotherapy and chemotherapy alone in PGIL.
Methods: We retrospectively reviewed and analyzed the treatment outcomes of 107 patients with primary gastrointestinal lymphoma diagnosed between March 1999 and December 2009 at Kosin University Gospel Hospital. Patients were divided into two groups: 35 patients who underwent surgery combined with chemotherapy (group A) and 72 patients who were treated with chemotherapy alone (group B). And we analyzed prognostic factors associated with short survival.
Results: The 5-year progression free survival rates (PFS) of group A and B were 86.7% and 66.1%, respectively (P = 0.037), while the 5-year overall survival rates (OS) were 86.8% and 68.4%, respectively (P = 0.129). In multivariate analysis, Both PFS and OS were not changed by treatment strategies (surgery combined with chemotherapy or chemotherapy only). The international prognostic index (IPI) was the only independent predictive factor for PFS.
Conclusions: In our study, surgery combined with chemotherapy and chemotherapy only make no difference of survival rate. And further randomized prospective studies are needed to confirm a treatment strategies at improving survival outcomes in PGIL patients.
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참고문헌 (22)
참고문헌 신청
LEE YJ / 2012 / Gastrointestinal lymphoma / Korean J Helicobacter Up Gastrointest Res 12:158~165
d'Amore F / 1994 / Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis / J Clin Oncol 12:1673~1684
Koch P / 2001 / Primary gastrointestinal non-Hodgkin's lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study / J Clin Oncol 19:3861~3873
Psyrri A / 2008 / Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management / Ann Oncol 19:1992~1999
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
d'Amore F / 1994 / Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis / J Clin Oncol 12:1673~1684
Koch P / 2001 / Primary gastrointestinal non-Hodgkin's lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study / J Clin Oncol 19:3861~3873
Psyrri A / 2008 / Primary extranodal lymphomas of stomach: clinical presentation, diagnostic pitfalls and management / Ann Oncol 19:1992~1999
김진만 / 2011 / WHO Classification of Malignant Lymphomas in Korea: Report of the Third Nationwide Study / Journal of Pathology and Translational Medicine 45(3):254~260
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