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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제61권 제2호
- 발행연도
- 2018.1
- 수록면
- 187 - 190 (4page)
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Two curcumin derivatives, demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC), isolated from Curcuma longa were analyzed for their inhibitory activities against two isoforms of monoamine oxidase (MAO), which is involved in the catalysis of neurotransmitting monoamines. In the study, DMC and BDMC potently inhibited human MAO-B, with $IC_{50}$ values of 2.45 and $2.59{\mu}M$, respectively, and both compounds showed effective inhibitory activities against human MAO-A, with $IC_{50}$ values of 3.24 and $3.09{\mu}M$, respectively. The inhibitory activities of the two compounds were higher than those of curcumin. The removal of the methoxy or dimethoxy groups in curcumin might increase the inhibitory activities against human MAO-A and MAO-B. The inhibited activities were recovered to almost the values of the reversible references in the dialysis experiments with DMC and BDMC. DMC and BDMC showed competitive inhibition for MAO-A and MAO-B, respectively, with $K_i$ values of 0.91 and $0.80{\mu}M$, respectively. These results suggest that the two curcumin derivatives may be useful or lead compounds in the treatment of related disorders as potent reversible MAO inhibitors.
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참고문헌 (21)
참고문헌 신청
Kulkarni SK / 2009 / Potentials of curcumin as an antidepressant / Scientific World Journal 9:1233~1241
Witkin JM / 2013 / Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin / CNS Neurol Disord Drug Targets 12:498~505
Ji HF / 2014 / The multiple pharmaceutical potential of curcumin in Parkinson's disease / CNS Neurol Disord Drug Targets 13:369~373
권영주 / 2014 / Curcumin as a Cancer Chemotherapy Sensitizing Agent / Applied Biological Chemistry 57(2):273~280
Parasuraman S / 2017 / Ameliorative effect of curcumin on olanzapine-induced obesity in Sprague-Dawley rats / Pharmacognosy Res 9:247~252
Witkin JM / 2013 / Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin / CNS Neurol Disord Drug Targets 12:498~505
Ji HF / 2014 / The multiple pharmaceutical potential of curcumin in Parkinson's disease / CNS Neurol Disord Drug Targets 13:369~373
권영주 / 2014 / Curcumin as a Cancer Chemotherapy Sensitizing Agent / Applied Biological Chemistry 57(2):273~280
Parasuraman S / 2017 / Ameliorative effect of curcumin on olanzapine-induced obesity in Sprague-Dawley rats / Pharmacognosy Res 9:247~252
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