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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제62권 제1호
- 발행연도
- 2019.1
- 수록면
- 39 - 50 (12page)
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초록· 키워드
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Mitogen-activated protein (MAP) kinases play an important role in cell growth and differentiation, as well as the modulation of proinflammatory cytokines. The objective of this study was to examine the increase in the anti-inflammatory effect of Gentiana scabra Bunge (GSB), due to bioconversion with the Aspergillus kawachii crude enzyme, via inhibition of the $NF-{\kappa}B$ signaling and MAP kinase pathways in RAW 264.7 cells. The expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 in RAW 264.7 cells treated with the GSB ethyl acetate fraction bioconverted with A. kawachii crude enzyme (GE-BA), was dramatically suppressed as compared to GSB ethyl acetate fraction non-bioconverted with the A. kawachii crude enzyme (GE-UA). The phosphorylation of p38, extracellular signal-regulated kinases, and inhibitory ${\kappa}B$ in RAW 264.7 cells treated with GE-BA was further suppressed, as compared to exposure to GE-UA. Moreover, the mRNA expression of interleukin 6, interleukin 1-beta, and tumor necrosis $factor-{\alpha}$ was further suppressed by GE-BA, compared to GE-UA. Similarly, anti-oxidant activities, such as 2,2-diphenyl-1-picrylhydrazyl hydrate and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity, of GE-BA were further increased compared to GE-UA. These observations demonstrate that the anti-oxidant and anti-inflammatory activities of GSB ethyl acetate fraction increases as a result from bioconversion with the A. kawachii crude enzyme.
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참고문헌 (60)
참고문헌 신청
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Li S / 2015 / BPIC : A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals / Bioorg Med Chem Lett 25:1146~1150
Daabis RG / 2016 / Hypogonadism in patients with chronic obstructive pulmonary disease : relationship with airflow limitation, muscle weakness and systemic inflammation / Alexandria Univ Facul Med 52:27~33
Westermann D / 2007 / Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy / Basic Res Cardiol 102:500~507
Wang F / 2015 / Blockade of TNF-α-induced NF-κB signaling pathway and anti-cancer therapeutic response of dihydrotanshinone I / Int Immuno 25:764~772
Li S / 2015 / BPIC : A novel anti-tumor lead capable of inhibiting inflammation and scavenging free radicals / Bioorg Med Chem Lett 25:1146~1150
Daabis RG / 2016 / Hypogonadism in patients with chronic obstructive pulmonary disease : relationship with airflow limitation, muscle weakness and systemic inflammation / Alexandria Univ Facul Med 52:27~33
Westermann D / 2007 / Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy / Basic Res Cardiol 102:500~507
Wang F / 2015 / Blockade of TNF-α-induced NF-κB signaling pathway and anti-cancer therapeutic response of dihydrotanshinone I / Int Immuno 25:764~772
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