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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국응용생명화학회 Journal of applied biological chemistry Journal of applied biological chemistry 제58권 제3호
- 발행연도
- 2015.1
- 수록면
- 227 - 232 (6page)
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초록· 키워드
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A microarray study has been employed to understand changes of gene expression in E. coli KD43162 resistant to ampicillin, ampicillin-sulbactam, piperacillin, piperacillin-tazobactam, cefazolin, cefepime, aztreonam, imipenem, meropenem, gentamicin, tobramycin, ciprofloxacin, levofloxacin, moxifloxacin, fosfomycin, and trimethoprim-sulfamethoxazole except for amikacin using disk diffusion assay. Using Sodium dodecyl sulphate-polyacrylamide gel electrophoresis and MALDI-TOF MS analyses, 36 kDa of outer membrane proteins (OMPs) was found to be deleted in the multidrug resistant E. coli KD 43162. Microarray analysis was used to determine up- and down-regulated genes in relation to multidrug resistant E. coli KD43162. Among the up-regulated genes, these genes were corresponded to express the proteins as penicillin-binding proteins (PBPs), tartronate semialdehyde reductase, ethanolamine utilization protein, shikimate kinase I, allantoinase, predicted SAM-dependent methyltransferase, L-glutamine: D-fructose-6-phosphate aminotransferase (GFAT), phospho-glucosamine mutase, predicted N-acetylmannosamine kinase, and predicted N-acetylmannosamine-6-P epimerase. Up-regulation of PBPs, one of primary target sites of antibiotics, might be responsible for the multidrug resistance in E. coli with increasing amount of target sites. Up-regulation of GFAT enzyme may be related to the up-regulation of PBPs because GFAT produces N-acetylglucosamine, a precursor of peptidoglycans. One of GFAT inhibitors, azaserine, showed a potent inhibition on the growth of E. coli KD43162. In conclusion, up-regulation of PBPs and GFATs with the loss of 36 kDa OMP refers the multidrug resistance in E. coli KD 43162.
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참고문헌 (34)
참고문헌 신청
Barreteau H / 2008 / Cytoplasmic steps of peptidoglycan biosynthesis / FEMS Microbiol Rev 32:161~207
Chopra S / 2013 / A systematic quantitative proteomic examination of multidrug resistance in Acinetobacter baumannii / J Proteomics 84:17~39
Cierniak P / 2013 / Insights into mechanisms and proteomic characterization of Pseudomonas aeruginosa adaptation to a novel antimicrobial substance / PLoS One 8:e66862
Clarke B / 2003 / Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada / Emerg Infect Dis 9:1254~1259
CLSI / 2010 / Performance standards for antimicrobial susceptibility testing:Twenty-first informational supplement / Clinical and Laboratory Standards Institute
Chopra S / 2013 / A systematic quantitative proteomic examination of multidrug resistance in Acinetobacter baumannii / J Proteomics 84:17~39
Cierniak P / 2013 / Insights into mechanisms and proteomic characterization of Pseudomonas aeruginosa adaptation to a novel antimicrobial substance / PLoS One 8:e66862
Clarke B / 2003 / Cephamycin resistance in clinical isolates and laboratory-derived strains of Escherichia coli, Nova Scotia, Canada / Emerg Infect Dis 9:1254~1259
CLSI / 2010 / Performance standards for antimicrobial susceptibility testing:Twenty-first informational supplement / Clinical and Laboratory Standards Institute
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