Comparison of Effects of Hemoglobin Levels Upon Tumor Response among Cervical Carcinoma Patients Undergoing Accelerated Hyperfractionated Radiotherapy versus Cisplatin Chemoradiotherapy

Thakur, Priyanka; Seam, Rajeev Kumar; Gupta, Manoj Kumar; Rastogi, Madhup; Gupta, Manish; Bhattacharyya, Tapesh; Sharma, Mukesh; Revannasiddaiah, Swaroop

추천

검색

자료유형: 학술저널

저자정보: Thakur, Priyanka (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Seam, Rajeev Kumar (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Gupta, Manoj Kumar (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Rastogi, Madhup (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Gupta, Manish (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Bhattacharyya, Tapesh (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Sharma, Mukesh (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College) Revannasiddaiah, Swaroop (Department of Radiotherapy, Regional Cancer Centre, Indira Gandhi Medical College)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제10호

발행연도: 2015.1

수록면: 4,285 - 4,289 (5page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Purpose: Blood hemoglobin levels are known to influence response to radiotherapy. This retrospective analysis compared the effect of hemoglobin levels upon response to radiation among patients treated with radiation alone (by accelerated hyperfractionated radiotherapy) versus those treated with concurrent cisplatin chemoradiotherapy. Materials and Methods: Among patients treated for locally advanced carcinoma of the cervix (LACC) during 2009-10, a total of 60 fulfilled the eligibility criteria. In this time frame, external beam radiotherapy was delivered with either concurrent chemoradiotherapy (CRT, n=31) (45Gy over 25 fractions, with weekly cisplatin at 40mg/m2), or with accelerated hyperfractionated radiotherapy (AHRT, n=29) (20Gy over 10 daily fractions over the first two weeks, followed by 30Gy over 20 fractions over the next two weeks, with two fractions of 1.5Gy per day, without the use of chemotherapy). Mean weekly hemoglobin (MWH) levels of all patients were calculated as the arithmetic means of weekly recorded blood hemoglobin levels. As per MWH, patients in both of the AHRT or the CRT groups were classified into two subgroups-those with MWH between 10-10.9g/dL, or with MWH>11g/dL. Complete response (CR) to external beam RT phase (prior to brachytherapy) was declared after clinical examinations and computed tomography. The CR rate was noted for both MWH sub-groups within each of the AHRT and CRT groups. Results: Within the AHRT group, patients with MWH>11g/dL had a much better CR rate in comparison to those with MWH:10-10.9g/dL (80% vs. 21.1%) which was statistically significant (p 0.0045). Within the CRT group, there was no significant difference in the outcomes within the MWH>11g/dL and MWH:10-10.9g/dL sub-groups (CR rates of 80% vs. 61.9%, p=0.4285). Conclusions: The importance of maintaining a minimum hemoglobin level of 11g/dL during RT is much greater for patients treated with RT alone, than for patients treated with concurrent chemoradiotherapy. Enhanced haemoglobin levels during RT may to an extent negate the ill-effects that may otherwise arise due to non-use of concurrent chemotherapy.

#Hemoglobin during radiotherapy #locally advanced cervical cancer #concurrent chemoradiotherapy

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!