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- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.5
- 수록면
- 53 - 53 (1page)
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Euonymus alatus (EA) has been used as an herbal medicine with its anti-hyperglycemic, anti-inflammatory, immune-modulating activities. However, the role of EA in allergic rhinitis (AR) remains unknown. Therefore, we investigated whether EA has a protective effect on an ovalbumin (OVA)-induced AR mouse model.
An AR mouse model was established by intraperitoneal injection and intranasal application of OVA to mice. Mice were orally administered various doses of EA once daily (50, 100, 200 mg/kg) and dexamethasone (Dex; 2.5 mg/kg) one hour before the challenge. Allergic nasal symptoms were observed. The levels of OVA-specific immunoglobulins (Ig), cytokines, and transcription factors were measured. The nasal and lung histopathology were evaluated.
EA administration significantly alleviated the nasal symptoms such as rubbing and sneezing. The altered histology of nasal and lung ... 전체 초록 보기
An AR mouse model was established by intraperitoneal injection and intranasal application of OVA to mice. Mice were orally administered various doses of EA once daily (50, 100, 200 mg/kg) and dexamethasone (Dex; 2.5 mg/kg) one hour before the challenge. Allergic nasal symptoms were observed. The levels of OVA-specific immunoglobulins (Ig), cytokines, and transcription factors were measured. The nasal and lung histopathology were evaluated.
EA administration significantly alleviated the nasal symptoms such as rubbing and sneezing. The altered histology of nasal and lung ... 전체 초록 보기
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