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논문 기본 정보

자료유형
학술저널
저자정보
Yan Jing Fan (Jeonbuk National University Medical School) Juan Jin (Jeonbuk National University Medical School) Chun Hua Piao (Jeonbuk National University Medical School) Thi Van Nguyen (Jeonbuk National University Medical School) You-Suk Kim (Goldtree) Ok Hee Chai (Jeonbuk National University Medical School) Chang Ho Song (Jeonbuk National University Medical School)
저널정보
대한체질인류학회 해부·생물인류학 해부·생물인류학 제36권 제3호
발행연도
2023.9
수록면
127 - 138 (12page)

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초록· 키워드

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Allium hookeri (A. hookeri) has been used as a traditional medicine for many years in the Southeast Asian region. Multiple investigations have demonstrated its role in preventing of microbial infection, immune regulation, coronary thrombosis, and atherosclerosis has been demonstrated by several studies. Therefore, this study aims to investigate the suppressing effect of A. hookeri on the ovalbumin (OVA)-induced allergic rhinitis (AR) murine model. In this study, AR was induced in BALB/c mice by using OVA emulsified in aluminum on days 1, 8 and 15. Then, nasally challenged with OVA on days 22 to 28. On days 16 to 28, OVA-induced mice were treated either with A. hookeri (50, 100, 200 mg/kg) or Dexamethasone (Dex, 2.5 mg/kg) by oral gavage. On days 22 to 28, mice received either A. hookeri (50, 100, 200 mg/kg) or Dexamethasone (Dex, 2.5 mg/kg) an hour before the OVA challenge. The mice in the control group were not sensitized, treated, or tested. In this study, A. hookeri ameliorated nasal symptoms include rubbing and sneezing; reduced thickness of nasal mucosa; alleviated goblet cell hyperplasia and eosinophil infiltration in the nasal mucosa; decreased levels of OVA-specific IgE and OVA-specific IgG1 in serum; and suppressed Th2 (IL-4, IL-5, and IL-13) cytokines level in nasal lavage fluid (NALF). In addition, A. hookeri recovered the production of Th1 (IL-12 and IFN-γ) cytokines level in NALF, inhibited the inflammation through NF-κB pathway. Collectively, our results suggest that A. hookeri effectively protects against AR by regulating Th1/Th2 cytokines imbalance and NF-κB mechanisms. These observations suggest A. hookeri as a potential therapeutic option for AR.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
DISCUSSION
CONCLUSION
REFERENCES

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