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논문 기본 정보
- 자료유형
- 학술대회자료
- 저자정보
- 발행연도
- 2021.7
- 수록면
- 174 - 174 (1page)
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Reduced of mitochondrial membrane potential (ΔΨm) in human cerebrospinal fluid (hCSF) was observed in subarachnoid hemorrhage (SAH) with delayed cerebral ischemia (DCI). However, the underlyin mechanism of mitochondrial dysfunction on subarachnoid hemorrhage (SAH) with delayed cerebral ischemia (DCI) has not been precisely elucidated yet. In this study, we examined the possibility of the mitochondrial dysfunction cause by autophagy and mitophagy in hCSF cells for possible insight into DCI pathogenesis. We collected CSF sample on 5 to 7 days from the 56 SAH patients (DCI, n=21; and non-DCI, n=35) treated with coil embolization. hCSF cells were analyzed using autophagy and mitophagy specific markers (DAPK1, BNIP3L, BAX, PINK1, ULK1, and NDP52) via qRT-PCR and western blotting of protein markers (pBECN1, BECN1, BNIP3L/NIX, DAPK1, PINK1, LC3, and P62). Compared with non-DCI, patients with DCI exhibited an significant induction of auto ... 전체 초록 보기
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