지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 170 - 174 (5page)
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초록· 키워드
오류제보하기
As a bisphosphonate, minodronate (MIN) is one of the strongest inhibitors of bone resorption. However, there have been no reports directly comparing the antiresorptive effects of monthly MIN with those of monthly risedronate (RIS). We enrolled 30 cases of osteoporosis (OP; 16 in the MIN group [mean age: 68.2 years] and 14 in the RIS group [mean age: 68.1 years]) to investigate the early effects of treatment by monthly MIN or RIS over a 4-month period using bone turnover marker values. Only female patients were enrolled to avoid gender bias. Urinary crosslinked N-telopeptide of type I collagen (NTX) before treatment and at 1, 2, and 4 months of therapy, as well as serum bone alkaline phosphatase and alkaline phosphatase before treatment and at 4 months afterwards, were evaluated. All bone turnover marker values were significantly decreased at 4 months in both groups. The changes in urinary NTX at the study end point for RIS and MIN were 30.1% and 63.1%, respectively. From 2 months of treatment, the antiresorptive effects on urinary NTX by MIN were significantly higher than those by RIS, indicating that MIN more immediately and strongly inhibited bone absorption. Thus, monthly MIN seems to suppress bone resorption faster and more strongly than RIS in OP treatment.
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Hagino H / 2015 / Bisphosphonate / Nihon Rinsho 73:1683~1689
Lyles KW / 2007 / HORIZON recurrent fracture trial. Zoledronic acid and clinical fractures and mortality after hip fracture / N Engl J Med 357:1799~1809
Beaupre LA / 2011 / Oral bisphosphonates are associated with reduced mortality after hip fracture / Osteoporos Int 22:983~991
Center JR / 2011 / Osteoporosis medication and reduced mortality risk in elderly women and men / J Clin Endocrinol Metab 96:1006~1014
Sambrook PN / 2011 / Oral bisphosphonates are associated with reduced mortality in frail older people: a prospective five-year study / Osteoporos Int 22:2551~2556
Lyles KW / 2007 / HORIZON recurrent fracture trial. Zoledronic acid and clinical fractures and mortality after hip fracture / N Engl J Med 357:1799~1809
Beaupre LA / 2011 / Oral bisphosphonates are associated with reduced mortality after hip fracture / Osteoporos Int 22:983~991
Center JR / 2011 / Osteoporosis medication and reduced mortality risk in elderly women and men / J Clin Endocrinol Metab 96:1006~1014
Sambrook PN / 2011 / Oral bisphosphonates are associated with reduced mortality in frail older people: a prospective five-year study / Osteoporos Int 22:2551~2556
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