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자료유형
학술저널
저자정보
김종대 (건양대학교) 강성주 (건양대학교) 이민경 (서남대학교) 박세은 (성균관대학교) 이은정 (성균관대학교) 박철영 (성균관대학교) 오기원 (성균관대학교) 박성우 (성균관대학교) 이원영 (성균관대학교)
저널정보
대한내분비학회 Endocrinology and Metabolism Endocrinology and Metabolism Vol.31 No.2
발행연도
2016.1
수록면
320 - 327 (8page)

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Background: Diabetes can be efficiently prevented by life style modification and medical therapy. So, identification for high risksubjects for incident type 2 diabetes is important. The aim of this study is to identify the best β-cell function index to identify highrisk subjects in non-diabetic Koreans. Methods: This is a retrospective longitudinal study. Total 140 non-diabetic subjects who underwent standard 2-hour 75 g oralglucose tolerance test from January 2007 to February 2007 at Kangbuk Samsung Hospital and followed up for more than 1 yearwere analyzed (mean follow-up, 54.9±16.4 months). The subjects were consist of subjects with normal glucose tolerance (n=44)and subjects with prediabetes (n=97) who were 20 years of age or older. Samples for insulin and C-peptide levels were obtainedat 0 and 30 minutes at baseline. Results: Thirty subjects out of 140 subjects (21.4%) developed type 2 diabetes. When insulin-based index and C-peptide-basedindex are compared between progressor and non-progressor to diabetes, all C-peptide-based indices were statistically differentbetween two groups, but only insulinogenic index and disposition index among insulin-based index were statistically different. C-peptide-based index had higher value of area under receiver operating characteristic curve (AROC) value than that of insulinbasedindex. “C-peptidogenic” index had highest AROC value among indices (AROC, 0.850; 95% confidence interval, 0.761 to0.915). C-peptidogenic index had significantly higher AROC than insulinogenic index (0.850 vs. 0.731 respectively; P=0.014). Conclusion: C-peptide-based index was more closely related to incident type 2 diabetes in non-diabetic subjects than insulinbasedindex.

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