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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 216 - 222 (7page)
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초록· 키워드
오류제보하기
C-peptide is the best indicator of endogenous insulin secretion in patients with diabetes. This study investigated the relationship between C-peptide levels and clinical/laboratory parameters of children with type 1 diabetes mellitus (T1DM), as measured at 6-month intervals after diagnosis. We retrospectively reviewed the data of 34 children with newly diagnosed T1DM. The study subjects were subdivided into a rapid progression group with C-peptide levels ＜0.6 ng/mL at 36 months (n=27; Group A) and a slow progression group with C-peptide levels ＞0.6 ng/mL at 36 months (n=7; Group B). Patients in Group A had a younger mean age at diagnosis (A: 9±4.3 years vs. B: 13.6±3.6 years; p=0.013) and lower body mass index (BMI) (A: 15.5±2.5 kg/m2 vs. B: 18.7±3.3 kg/m2; p=0.035). There were fewer asymptomatic patients with glucosuria in Group A, with these patients showing more severe symptoms, such as diabetic ketoacidosis (p=0.035), than those in Group B. Group A also had lower initial C-peptide levels (A: 0.5±0.46 ng/mL vs. B: 1.87±1.08 ng/mL; p=0.001). There were no significant intergroup differences in sex, family history, baseline hemoglobin A1c (HbA1c), potential of hydrogen (pH), autoantibodies or serum insulin. Simple correlation analyses showed that C-peptide levels were correlated with age and BMI, but not with pH, insulin, or HbA1c. Younger patients, who had a lower BMI, significant symptoms with complications, and/or a low initial C-peptide level, tended to show a rapid rate of decrease in C-peptide levels. Early intensive insulin therapy to preserve beta-cell function should be considered in these groups.
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등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Jones AG / 2013 / The clinical utility of C-peptide measurement in the care of patients with diabetes / Diabet Med 30:803~817
Ludvigsson J / 2012 / C-peptide in the classification of diabetes in children and adolescents / Pediatr Diabetes 13:45~50
Steck AK / 2016 / Predictors of slow progression to diabetes in children with multiple islet autoantibodies / J Autoimmun 72:113~117
Achenbach P / 2013 / Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children / Diabetologia 56:1615~1622
Redondo MJ / 2012 / Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes / Pediatr Diabetes 13:564~571
Ludvigsson J / 2012 / C-peptide in the classification of diabetes in children and adolescents / Pediatr Diabetes 13:45~50
Steck AK / 2016 / Predictors of slow progression to diabetes in children with multiple islet autoantibodies / J Autoimmun 72:113~117
Achenbach P / 2013 / Characteristics of rapid vs slow progression to type 1 diabetes in multiple islet autoantibody-positive children / Diabetologia 56:1615~1622
Redondo MJ / 2012 / Beta cell function and BMI in ethnically diverse children with newly diagnosed autoimmune type 1 diabetes / Pediatr Diabetes 13:564~571
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