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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 296 - 304 (9page)
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Background: Vitamin D plays an important role in the immune response against infection. The purpose of the present study was to investigate the influence of vitamin D deficiency on the progression of otitis media (OM) using an experimental rat model. Methods: Four-week-old male Sprague-Dawley rats (n=72) were divided into two groups based on their diet: a control diet group (n=36) and a vitamin D-deficient diet group (n=36). After 8 weeks of diet, experimental OM was induced by inoculation of non-typeable Haemophilus influenzae in the middle ear cavity. The rats were evaluated with otomicroscopy to determine the inflammation in the middle ear mucosa on days 1, 2, 4, 7, and 14 post-inoculation. Bullae from sacrificed rats were collected and analyzed histologically. Results: The middle ear mucosa from rats with vitamin D deficiency showed a significantly higher thickness than that of controls during the course of OM. The maximum mucosal thickness was 56.0±9.1 μm in the vitamin D deficiency group, and 43.9±9.8 μm in the control group, although there was no significant difference in the tympanic membrane score between the two groups evaluated with otomicroscopy. An immunohistochemical study showed increased expression of interleukin 6 (IL-6) and tumor necrosis factor α in rats manifesting vitamin D deficiency and decreased expression of IL-10 compared with controls. Conclusion: Our results showed that vitamin D deficiency may exacerbate the pathophysiological changes of OM via altered cytokine production. Therefore, maintaining vitamin D status in the optimal range may be beneficial for proper management of OM.
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참고문헌 (21)
참고문헌 신청
Prietl B / 2013 / Vitamin D and immune function / Nutrients 5:2502~2521
Gunville CF / 2013 / The role of vitamin D in prevention and treatment of infection / Inflamm Allergy Drug Targets 12:239~245
Borella E / 2014 / Vitamin D: a new anti-infective agent / Ann N Y Acad Sci 1317:76~83
Bouillon R / 2008 / Vitamin D and human health: lessons from vitamin D receptor null mice / Endocr Rev 29:726~776
Rathored J / 2012 / Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D / Int J Tuberc Lung Dis 16:1522~1528
Gunville CF / 2013 / The role of vitamin D in prevention and treatment of infection / Inflamm Allergy Drug Targets 12:239~245
Borella E / 2014 / Vitamin D: a new anti-infective agent / Ann N Y Acad Sci 1317:76~83
Bouillon R / 2008 / Vitamin D and human health: lessons from vitamin D receptor null mice / Endocr Rev 29:726~776
Rathored J / 2012 / Risk and outcome of multidrug-resistant tuberculosis: vitamin D receptor polymorphisms and serum 25(OH)D / Int J Tuberc Lung Dis 16:1522~1528
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